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Conflict drives mpox epidemic in eastern DRC.
Science
December 2024
Uganda MoH Scientific Advisory Committee on Epidemics and Division of Pathogen OMICS, Unit of Genetics & Genomics, Departments of Pathology, Immunology, and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.
Concurrent outbreaks of mpox in Africa-an update.
Lancet
January 2025
Skin Neglected Tropical Diseases and Sexually Transmitted Infections Section, Fight Infectious Diseases Foundation, University Hospital Germans Trias i Pujol, Badalona, Spain; Department of Medicine, Universitat Autónoma de Barcelona, Bellaterra, Spain; Infectious Diseases Department, Universitat de Vic-Universitat Central de Catalunya, Vic, Spain. Electronic address:
In this Review, we examine the concurrent outbreaks of mpox in Africa, focusing on clade 1a, the newly emerged clade 1b, and clade 2b lineage A, and how they differ from the 2022 global outbreak caused by clade 2b lineage B.1. Historically, clades 1a and 2a have caused sporadic, small outbreaks in central and west Africa, respectively, primarily through zoonotic transmission.
View Article and Find Full Text PDFLearning from over ten years of implementing the One Health approach in the Democratic Republic of Congo: A qualitative study.
One Health
December 2024
Section of Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Background: The Democratic Republic of Congo (DRC) has faced emerging infectious diseases such as Ebola, Mpox and Yellow fever, and antimicrobial resistance is a growing concern. To address these issues, in 2011 the country embarked on implementing the One Health (OH) approach at the national and provincial levels. This study investigates OH institutionalization and implementation in the DRC, describes the process of OH decentralization, and identifies the opportunities and challenges of sustaining these efforts.
View Article and Find Full Text PDFMpox in East Africa: Learning from COVID-19 and Ebola to Strengthen Public Health Responses.
Viruses
October 2024
Rwanda Biomedical Centre, Kigali P.O. Box 7162, Rwanda.
The Africa Centers for Disease Control and Prevention declared mpox a Public Health Emergency of Continental Security (PHECS) in Africa. African public health systems have moved to mobilize a response against a backdrop of inherent significant challenges. With this commentary, we discuss how lessons from past public health emergencies, particularly COVID-19 and Ebola outbreaks, have prepared the region for improved disease surveillance, rapid response strategies, and effective public health communication and how these lessons can be applied to the mpox response, emphasizing the importance of strong healthcare infrastructure, effective data sharing, community engagement, targeted interventions, and robust contact tracing.
View Article and Find Full Text PDFClade I mpox virus genomic diversity in the Democratic Republic of the Congo, 2018-2024: Predominance of zoonotic transmission.
Cell
January 2025
Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo. Electronic address:
Recent reports raise concerns on the changing epidemiology of mpox in the Democratic Republic of the Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether the increase in number of cases is due to zoonotic spillover events or viral evolution, with enrichment of APOBEC3 mutations linked to human adaptation. Our study highlights two patterns of transmission contributing to the source of human cases.
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