Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447786 | PMC |
| http://dx.doi.org/10.2105/AJPH.2024.307824 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Korth toxicity: Experimental findings and future prospects.
J Taibah Univ Med Sci
December 2024
Drug Discovery and Synthetic Chemistry Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
(Roxb.) Korth, locally known as kratom, is a traditional medicinal plant from Southeast Asia, with mitragynine as its principal alkaloid. Similar to other medicinal plants, kratom has side effects and toxicities, which have been documented in scientific studies and case reports.
View Article and Find Full Text PDFMonoterpene indole alkaloids (MIAs) are a large, structurally diverse class of bioactive natural products. These compounds are biosynthetically derived from a stereoselective Pictet-Spengler condensation that generates a tetrahydro-β-carboline scaffold characterized by a 3 stereocenter. However, a subset of MIAs contain a non-canonical 3 stereocenter.
View Article and Find Full Text PDFNetwork Pharmacology, Molecular Docking, and In Vitro Insights into the Potential of for Alzheimer's Disease.
Int J Mol Sci
December 2024
School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Korth. Havil (MS) has a traditional use in relieving pain, managing hypertension, treating cough, and diarrhea, and as a morphine substitute in addiction recovery. Its potential in addressing Alzheimer's disease (AD), a neurodegenerative condition with no effective treatments, is under investigation.
View Article and Find Full Text PDFThe neuropharmacology of kratom, a novel psychoactive natural product.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
College of Pharmacy, Department of Pharmaceutical Sciences, Midwestern University, Glendale, AZ, United States; College of Pharmacy, Department of Medicinal Chemistry, University of Florida, Gainesville, FL, United States. Electronic address:
Kratom (Mitragyna speciosa, Korth.) is a tropical tree that is indigenous to Southeast Asia. When ingested, kratom leaves or decoctions from the leaves have been reported to produce complex stimulant and opioid-like effects.
View Article and Find Full Text PDFExploring the cognitive effects of kratom: A review.
Behav Brain Res
March 2025
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, Erlangen, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:
Article Synopsis
- * Research has focused on kratom's effects on cognition, particularly its interactions with key receptors in the brain, which might impact cognitive function.
- * The main alkaloid in kratom, mitragynine, may negatively influence cognitive performance by disrupting synaptic plasticity and brain activity, highlighting the need for further study on its safety and therapeutic potential.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!