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First report of the chloroplast and mitochondrial genomes of the Indian pitcher plant, Nepenthes khasiana Hook.f.
BMC Res Notes
January 2025
Bioinformatics Center, North-Eastern Hill University, Shillong, 793022, India.
Objectives: Nepenthes, sometimes known as tropical pitcher plants or monkey cups, is a carnivorous plant genus that contains more than 160 species. Nepenthes khasiana, India's sole representative of the genus, is a rare and endangered dioecious plant endemic to North-east India. Despite the fact that it is a prominent insectivorous plant in the Nepenthaceae family, genomic resources for the species are limited, making genomic breeding and understanding the genetic basis of botanical carnivory difficult.
View Article and Find Full Text PDFAdvancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening.
Sci Rep
January 2025
Molecular Biology and Stem Cell Research Lab, Centre for Molecular and Nanomedical Sciences, International Research Centre, Sathyabama Institute of Science & Technology, Chennai, Tamilnadu, India.
Model organisms are vital for biomedical research and drug testing but face high costs, complexity, and ethical issues. While newer techniques like organoids and assembloids have shown improvements, they still remain inadequate in addressing all research needs. In this study, we present a new method for maintaining the prostate gland of the earthworm, Eudrilus eugeniae ex vivo and examine its potential for regeneration and drug screening.
View Article and Find Full Text PDFSite-specific substitution in atomically precise carboranethiol-protected nanoclusters and concomitant changes in electronic properties.
Nat Commun
January 2025
DST Unit of Nanoscience (DST UNS) and Thematic Unit of Excellence (TUE), Department of Chemistry, Indian Institute of Technology, Madras, Chennai, 600036, India.
We report the synthesis of [Ag(o-CBT)] abbreviated as Ag, a stable 8e⁻ anionic cluster with a unique Ag@Ag@Ag core-shell structure, where o-CBT is ortho-carborane-1-thiol. By substituting Ag atoms with Au and/or Cu at specific sites we created isostructural clusters [AuAg(o-CBT)] (AuAg), [AgCu(o-CBT)] (AgCu) and [AuAgCu(o-CBT)] (AuAgCu). These substitutions make systematic modulation of their structural and electronic properties.
View Article and Find Full Text PDFNanoscale Ligand Spacing Regulates Mechanical Force-Induced Cancer Cell Killing.
Nano Lett
January 2025
Department of Bioengineering, Indian Institute of Science, Bangalore 560012, India.
Cancer cells sense and respond to the extracellular environment, with differences in nanoscale ligand spacing affecting their behavior. Emerging reports show that stretch/ultrasound-mediated mechanical forces promote apoptosis (mechanoptosis) by increasing myosin contractility. Since myosin contractility is critical for nanoscale-ligand spacing-regulated cell behavior, we study the effect of ligand spacing on mechanoptosis.
View Article and Find Full Text PDFVoxRad: Building an open-source locally-hosted radiology reporting system.
Clin Imaging
January 2025
LN Medical College & JK Hospital, Kolar Road, Bhopal, Madhya Pradesh, India. Electronic address:
VoxRad is an open-source application designed to enhance radiology reporting by leveraging generative AI. Utilizing locally hosted Automatic Speech Recognition (ASR) and Large Language Models (LLM), VoxRad enables continuous dictation, transcribing reports into standardized formats with high accuracy, efficiency, and data security. The modular design allows flexible integration of user-selected ASR and LLM models via OpenAI-compatible APIs, ensuring HIPAA compliance with secure local storage of data.
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