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Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays.
DNA Repair (Amst)
January 2025
School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 6997801, Israel; Edmond J. Safra Center for Bioinformatics, Tel Aviv University, Tel Aviv 6997801, Israel; Department of Biomedical Engineering, Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address:
Quantitative genomic mapping of DNA damage may provide insights into the underlying mechanisms of damage and repair. Sequencing based approaches are bound to the limitations of PCR amplification bias and read length which hamper both the accurate quantitation of damage events and the ability to map them to structurally complex genomic regions. Optical Genome mapping in arrays of parallel nanochannels allows physical extension and genetic profiling of millions of long genomic DNA fragments, and has matured to clinical utility for characterization of complex structural aberrations in cancer genomes.
View Article and Find Full Text PDFBiosorption of cobalt (II) from an aqueous solution over acid modified date seed biochar: an experimental and mass transfer studies.
Environ Sci Pollut Res Int
January 2025
Department of Chemical Engineering, Zakir Hussain College of Engineering and Technology, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Water pollution because of the presence of heavy metals remains a serious worry. The present work demonstrates the exclusion of cobalt ion (or Co(II)) from water using novel and cost-effective biosorbents. Initially, the biosorbent was chemically modified using orthophosphoric acid and then subjected to calcination to result acid modified date seed biochar (AMDB).
View Article and Find Full Text PDFIn situ decoration of AuPd nanoparticles on MOF derived ZnO for ultra-high response and low detection limit trimethylamine detection.
Anal Chim Acta
February 2025
School of Physics and Electronic Information Engineering, Henan Polytechnic University, Jiaozuo, 454003, China. Electronic address:
Background: Trimethylamine (TMA) is a colorless, volatile gas with a strong irritating odor. Prolonged exposure to a certain amount of TMA can cause symptoms such as dizziness, nausea and difficulty breathing, and may even be life-threatening. Therefore, effective detection of TMA is crucial.
View Article and Find Full Text PDFBlarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial.
J Prev Alzheimers Dis
January 2025
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
CaCO-coated indoxacarb deep eutectic solvent complexed with diatomaceous earth improves insecticidal activity against the red imported fire ants.
Ecotoxicol Environ Saf
January 2025
School of Tropical Agriculture and Forestry, Hainan University, Danzhou, Hainan 570228, China. Electronic address:
The red imported fire ants (RIFAs) are a globally important invasive pest that severely affects the ecosystem and human health, and its current control is primarily through chemical pesticides. However, the extensive use of chemical pesticides causes environmental problems, and alternative strategies for controlling this pest are being explored. In our study, we aimed to design a deep eutectic solvent (DES)-CaCO system in which RIFAs were used as target insects to increase the lethal activity and behavioural regulation effects on RIFAs via contact and feeding.
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