Antibiotic Lock Therapy (ALT) for the prevention of Catheter Related Blood Stream Infection (CRBSI) in neurological patients treated with Therapeutic Plasma Exchange (TPE).

•Catheter related blood stream infection (CRBSI) is associated with several debilitating consequences for patients and medical institutions.•Antibiotic lock therapy (ALT) significantly reduced the incidence of CRBSI in patients receiving therapeutic plasma exchange (TPE).•Antibiotic lock therapy (ALT) reduced the medical care costs•ALT should be considered an acceptable and reasonable approach for patients receiving TPE.