AI Article Synopsis
- Research explored the link between calcium intake, genetic variants in the calcium sensor receptor gene, and survival rates in colorectal cancer (CRC) patients, using data from 18,952 individuals.
- No significant associations were found between dietary, supplemental, or total calcium intake and either all-cause or CRC-specific mortality, despite tracking 6,801 deaths over a median follow-up of 4.8 years.
- The study noted potential interactions between supplemental calcium intake and certain genetic variants, suggesting that genetics may influence how calcium affects mortality in CRC patients.
Article Abstract
Background: Research on calcium intake as well as variants in the calcium sensor receptor ( gene and their interaction in relation to CRC survival is still limited.
Methods: Data from 18,952 CRC patients, were included. Associations between primarily pre-diagnostic dietary ( = 13.085), supplemental ( = 11,837), total calcium intake ( = 5970) as well as 325 single nucleotide polymorphisms (SNPs) of the gene ( = 15,734) in relation to CRC-specific and all-cause mortality were assessed using Cox proportional hazard models. Also interactions between calcium intake and variants in the gene were assessed.
Results: During a median follow-up of 4.8 years (IQR 2.4-8.4), 6801 deaths occurred, of which 4194 related to CRC. For all-cause mortality, no associations were observed for the highest compared to the lowest sex- and study-specific quartile of dietary (HR 1.00, 95%CI 0.92-1.09), supplemental (HR 0.97, 95%CI 0.89-1.06) and total calcium intake (HR 0.99, 95%CI 0.88-1.11). No associations with CRC-specific mortality were observed either. Interactions were observed between supplemental calcium intake and several SNPs of the gene.
Conclusion: Calcium intake was not associated with all-cause or CRC-specific mortality in CRC patients. The association between supplemental calcium intake and all-cause and CRC-specific mortality may be modified by genetic variants in the gene.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368808 | PMC |
| http://dx.doi.org/10.1038/s44276-024-00077-3 | DOI Listing |
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