AI Article Synopsis
- Women may experience significant changes in depressive symptoms during the menopause transition, particularly around the final menstrual period (FMP).
- A study involving over 1,500 multiracial women tracked depressive symptoms over time, noting that those with high initial symptoms tended to improve until four years before the FMP, while those with low symptoms experienced an increase until a year before the FMP.
- Factors such as social support and hormonal levels were linked to decreases in symptoms, while anxiety and stressful life events predicted increases in depressive symptoms among those initially reporting low symptoms.
Article Abstract
Background: Women may be vulnerable to elevated depressive symptoms during the menopause transition (MT). Studies generally have not considered premenopausal depressive symptom history or examined symptoms in relation to the final menstrual period (FMP).
Objective: To identify specific time points in relation to the FMP when depressive symptoms increase or decrease.
Methods: Participants were 1582 multiracial/ethnic women from the longitudinal Study of Women's Health Across the Nation (SWAN). Biological, psychosocial, and depressive symptom data were collected approximately annually. Depressive symptoms were measured by the Center for Epidemiological Studies-Depression (CESD) scale.
Results: Women with high baseline depressive symptoms (CES-D ≥ 16) declined in symptoms (M = -1.04/yr., 95 % CI = -1.58, -0.50) until 4 years before the FMP, followed by a smaller decrease (M = -0.50/yr., 95 % CI = -0.72, -0.28) until 18 months after the FMP. Depressive symptoms increased (M = 0.21/yr., 95 % CI = 0.11, 0.30) in those with low baseline symptoms until 1 year before the FMP, and decreased (M = -0.06/yr., 95 % CI = -0.11, -0.008) going forward. Greater social support, higher levels of follicle stimulating hormone and estradiol, and less sleep disturbance contributed to greater decline in depressive symptoms among those with high baseline depressive symptoms. Anxiety, experiencing stressful life events, lower body mass index, and poor role-physical function contributed to an increase in depressive symptoms among those with low baseline symptoms.
Limitations: Excluded women had higher baseline CES-D scores. Lacked pre-MT depression for pre/early perimenopausal women at baseline.
Conclusion: Accounting for baseline depressive symptom level and focusing on the FMP more precisely characterize depressive symptom change over the MT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495996 | PMC |
| http://dx.doi.org/10.1016/j.jad.2024.08.237 | DOI Listing |
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