AI Article Synopsis
- Metastasis in colorectal cancer (CRC) worsens patient outcomes, and long noncoding RNAs (lncRNAs) play a crucial role in this process, though mechanisms are not fully understood.
- The study identifies lncRNA SNHG1, found at higher levels in metastatic CRC tissues, as a key factor that promotes tumor cell migration and invasion.
- SNHG1 enhances the stability of SERPINA3 mRNA through its interaction with HNRNPD protein, suggesting that targeting this lncRNA/HNRNPD/SERPINA3 pathway could be a potential treatment strategy to reduce CRC metastasis.
Article Abstract
Metastasis continues to negatively impact individuals diagnosed with colorectal cancer (CRC). Research has revealed the important role of long noncoding RNAs (lncRNAs) in CRC metastasis, but the underlying mechanisms remain unclear. Here, we revealed that the lncRNA small nucleolar RNA host gene 1 (SNHG1) is expressed at higher levels in metastatic CRC tissues than in primary CRC tissues, and that high lncRNA SNHG1 expression indicates poor patient outcomes. We found that lncRNA SNHG1 promotes the migration and invasion of tumor cells both in vivo and in vitro. Moreover, lncRNA SNHG1 increases serpin family A member 3 (SERPINA3) mRNA stability by interacting with the heterogeneous nuclear ribonucleoprotein D (HNRNPD) protein, and subsequently upregulates SERPINA3 expression. Moreover, HNRNPD and SERPINA3 reversed the effects of lncRNA SNHG1 knockdown on CRC cell metastasis. In conclusion, we report that the lncRNA SNHG1 recruits HNRNPD, in turn upregulating SERPINA3 expression and ultimately facilitating CRC cell migration and invasion. Targeting the lncRNA SNHG1/HNRNPD/SERPINA3 signaling pathway might be a therapeutic option for preventing CRC metastasis.
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| http://dx.doi.org/10.1016/j.canlet.2024.217217 | DOI Listing |
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