AI Article Synopsis
- Lipid droplets (LDs) are dynamic organelles that play a key role in regulating metabolism and energy in cells, interacting with various lipid-associated proteins.
- A literature review from 2013 to 2024 identified 91 studies focusing on the interactions between LDs and 10 natural compounds, using data from multiple research databases.
- Natural compounds like Berberine, Capsaicin, and Resveratrol show potential in improving lipid droplet function and may offer therapeutic benefits for metabolic diseases.
Article Abstract
Background: Lipid droplet (LD) is a metabolically active organelle, which changes dynamically with the metabolic state and energy requirements of cells. Proteins that either insert into the LD phospholipid monolayer or are present in the cytoplasm, playing a crucial role in lipid homeostasis and signaling regulation, are known as LD-associated proteins.
Methods: The keywords "lipid droplets" and "metabolic diseases" were used to obtain literature on LD metabolism and pathological mechanism. After searching databases including Scopus, OVID, Web of Science, and PubMed from 2013 to 2024 using terms like "lipid droplets", "lipid droplet-associated proteins", "fatty liver disease", "diabetes", "diabetic kidney disease", "obesity", "atherosclerosis", "hyperlipidemia", "natural drug monomers" and "natural compounds", the most common natural compounds were identified in about 954 articles. Eventually, a total of 91 studies of 10 natural compounds reporting in vitro or in vivo studies were refined and summarized.
Results: The most frequently used natural compounds include Berberine, Mangostin, Capsaicin, Caffeine, Genistein, Epigallocatechin-3-gallate, Chlorogenic acid, Betaine, Ginsenoside, Resveratrol. These natural compounds interact with LD-associated proteins and help ameliorate abnormal LDs in various metabolic diseases.
Conclusion: Natural compounds involved in the regulation of LDs and LD-associated proteins hold promise for treating metabolic diseases. Further research into these interactions may lead to new therapeutic applications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373146 | PMC |
| http://dx.doi.org/10.1186/s13020-024-00988-w | DOI Listing |
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