A photocatalytic process was devised to synthesize monofluoroalkenes via defluorinative functionalization of allylic difluorides. -Alkylanilines are used as precursors to α-aminoalkyl radicals, which undergo regioselective addition to allylic difluorides, and subsequent SET and fluoride elimination produce monofluoroalkenes. C-C bond formation on the aniline is site-selective for the least substituted carbon α to nitrogen.
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| http://dx.doi.org/10.1021/acs.joc.4c01861 | DOI Listing |
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