Background: The breath carbon isotope ratio (CIR) was recently identified as a noninvasive candidate biomarker of short-term added sugars (AS) intake.
Objectives: This study aimed to better understand the potential of the breath CIR as a dietary biomarker. We evaluated the effects of short-term and long-term intakes of AS, animal protein (AP), and related variables on breath CIR, in the context of typical dietary intake patterns.
Methods: We conducted a 15-d controlled feeding study of 100 adults (age 18-70 y, 55% females) in Phoenix, AZ. Participants were provided individualized diets that approximated habitual food intakes and recorded the timing of food consumption. Three breath samples (fasting, midday, and evening) were collected on each of 3 nonconsecutive study days. We modeled the effects of dietary intake in each of 8 h preceding collection of the breath sample on breath CIR with a linear mixed model, which also included 15-d mean intakes, sex, age, and BMI.
Results: Median (IQR) intakes of AS and AP in our study were 65 (38) and 67 (33) g/d, respectively. Midday and evening breath CIRs correlated strongly with each other (0.80) and with fasting breath CIR (0.77 and 0.68, respectively). In our linear mixed models, breath CIR increased by AS consumed 1-4 h before sample collection, AP consumed 3-6 h before sample collection, and 15-d intakes of AS and AP, all with similar effect sizes. The breath CIR was also inversely associated with 15-d intakes of intrinsic sugars and plant protein; thus, associations with 15-d intakes were particularly strong when expressed proportionally as the AS ratio (added sugars/total sugars) and AP ratio (animal protein/total protein).
Conclusions: The breath CIR is a promising measure of long-term intakes of AS and AP, especially as proportional intakes. Approaches to increase specificity would benefit the further development of this biomarker.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393392 | PMC |
| http://dx.doi.org/10.1016/j.ajcnut.2024.05.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance.
Cell Metab
November 2024
Nestlé Institute of Health Sciences, Nestlé Research, Société des Produit Nestlé S.A., EPFL Innovation Park, 1015 Lausanne, Switzerland. Electronic address:
Article Synopsis
- Mitochondrial calcium uniporter (MCU) plays a crucial role in calcium uptake and energy metabolism, especially during muscle contractions, but its therapeutic potential in aging-related muscle decline is not well understood.
- Research reveals that the regulator MCUR1 is downregulated in aging muscles, leading to reduced mitochondrial calcium uptake and impaired energy production, contributing to sarcopenia (muscle loss).
- The natural compound oleuropein has been identified as an activator of MCU, which enhances mitochondrial function and endurance in both young and older mice, indicating its potential as a food-derived treatment for age-related muscle dysfunction.
Treatment effectiveness according to frequencies in patients with sudden sensorineural hearing loss.
Cir Cir
November 2024
Department of Otorhinolaryngology, Memorial Diyarbakır Hospital, Diyarbakır. Turkey.
Article Synopsis
- The study investigates the effects of combining hyperbaric oxygen therapy (HBOT) with steroid treatment on patients suffering from sudden sensorineural hearing loss (SSNHL).
- It involved 50 participants who received intravenous steroids and underwent HBOT, with improvements in hearing observed across various frequencies after treatment.
- Results indicated significant enhancement in hearing, particularly at lower frequencies, suggesting that the combination therapy is effective for SSNHL patients.
The 100 most influential articles in mouth breathing. A bibliometric and altmetric analysis: 2002-2021.
Med Oral Patol Oral Cir Bucal
January 2025
Department of Information and Communication Faculty of Communication and Documentation Colegio Máximo. Campus de Cartuja s/n University of Granada, 18071 Granada, Spain
Background: This study aimed to identify and analyze the most influential Mouth Breathing (MB) articles in children and adolescents with the highest relative citation rates (RCRs), through bibliometric and altmetric analysis, from 2002 to 2021.
Material And Methods: On March 27, 2023 a PubMed search was conducted to detect papers published about MB. From a total of 826 documents, the article data were downloaded from iCite database.
Acute kidney injury and mortality in patients with critical COVID-19 in Mexico: case-control study.
Cir Cir
October 2024
Health Services of the State of Queretaro.
Objective: We aimed to test the association between acute kidney injury (AKI) and mortality in critically ill patients with Coronavirus disease 2019 (COVID-19).
Method: We conducted a single-center case-control study at the intensive care unit (ICU) of a second-level hospital in Mexico. We included 100 patients with critical COVID-19 from January to December 2021, and collected demographic characteristics, comorbidities, APACHE II, SOFA, NEWS2, and CO-RADS scores at admission, incidence of intrahospital complications, length of hospital and ICU stay, and duration of mechanical ventilation, among others.
A call for compassionate opioid overdose response.
Int J Drug Policy
November 2024
T. Stephen Jones Public Health Consulting, 123 Black Birch Trail, Florence MA 01062, USA. Electronic address:
High dose and long-acting opioid overdose reversal drugs can precipitate withdrawal in people who are opioid dependent. Products recently brought to market for community use in the United States (US) have drawn international concern because of their increased risk of withdrawal. At the March 18-19, 2024, Compassionate Overdose Response Summit & Naloxone Dosing Meeting, a panel of harm reduction experts issued the following call to action: 1) people who use drugs should be directly involved in decisions regarding the research, development, selection, and distribution of opioid overdose reversal products; 2) regulatory agencies and pharmaceutical manufacturers should carefully consider and communicate the risk and duration of withdrawal associated with higher dose and longer-acting opioid antagonists; 3) take-home naloxone kits should include at least two doses of an intramuscular (IM) product containing 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!