Capillary flow profile of liquid samples in porous media is closely related to the important properties of liquid samples, including the viscosity and the surface energy. Therefore, capillary flow profile can be used as an index to differentiate liquid samples with different properties. Fast and automatic characterization of capillary flow profile of liquid samples is necessary. In this work, we develop a portable and economical capacitance acquisition system (CASY) to easily obtain the capillary flow profile of liquid samples on microfluidic thread-based analytical devices (μTADs) by measuring the capacitance during the capillary flow. At first, we validate the accuracy of this method by comparing with the traditional method by video analysis in obtaining the capillary flow profiles in μTADs of cotton threads or glass fiber threads. Then we use it to differentiate liquid samples with different viscosity (mixture of water and glycerol). In addition, capillary flow profile on μTADs with chemical valves (chitosan or sucrose) can also be obtained on this device. Lastly, we show the potential of this device in measurement of hematocrit (HCT) of whole blood samples. This device can be used to catalog liquid biological samples with different properties in point-of-care diagnostics in the near future.
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http://dx.doi.org/10.1016/j.chroma.2024.465328 | DOI Listing |
J Biomech
December 2024
Research and Development Center of Biomedical Photonics, Orel State University, Orel, Russia.
Although there is currently sufficient information on various parameters of capillary blood flow, including the average values of blood velocity, there is no data on the dynamics of velocity and the mechanisms of its modulation in various parts of the capillary. The main idea of this work is to develop a tool and image data processing to study the characteristics of the capillary blood flow dynamics. In this study, using the developed method of high-speed videocapillaroscopy, the red blood cells (RBC) velocities in the arterial and venous parts of the nailfold capillaries were compared and a time-frequency analysis of the dynamics of the velocity signals with the calculation of phase coherence was performed.
View Article and Find Full Text PDFJ Chromatogr A
December 2024
KU Leuven - University of Leuven, Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, O&N2, PB 923, Herestraat 49 3000 Leuven, Belgium. Electronic address:
Natural products (NPs) play an important role in drug discovery and drug development due to their diverse chemical properties and biological activities. In the present work, an on-line capillary electrophoresis (CE) method was developed and applied to screen protein tyrosine phosphatase 1B (PTP1B) inhibitors in NPs. As a generic technique, transverse diffusion of laminar flow profiles (TDLFP) was utilized to mix all reactants in the capillary for on-line enzymatic reaction.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
January 2025
Heat Transfer and Thermal Power Laboratory, Department of Mechanical Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India.
Chronic obstructive pulmonary disease (COPD) is a primary chronic respiratory disease associated with pulmonary congestion that restricts airflow and thereby affects the exchange of gases between the alveoli and the blood capillaries in the lungs. Dual scale-global and local-porous medium models have been developed and reported in this work, to study the effects of air-side congestion on the blood-oxygen content in the alveolar region of the human lung. The human lung is model as a global, equivalent, heterogeneous porous medium comprising three zones with distinct permeabilities related to their progressively complex branching structure.
View Article and Find Full Text PDFActa Biomater
December 2024
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:
The lymphatic system plays an important role in health and many diseases, such as cancer, autoimmune, cardiovascular, metabolic, hepatic, viral, and other infectious diseases. The lymphatic system is, therefore, an important treatment target site for a range of diseases. Lymph nodes (LNs), rich in T cells, B cells, dendritic cells, and macrophages, are also primary sites of action for vaccines and immunotherapies.
View Article and Find Full Text PDFImmun Inflamm Dis
December 2024
Department of Geriatric Intensive Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
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