AI Article Synopsis
- The study investigates the high failure rate of rotator cuff repairs, especially in diabetic patients, and the unclear effects of Polydeoxyribonucleotide (PDRN) and polynucleotide (PN) on tendon healing.
- In a diabetic rat model with chronic rotator cuff tears, administering PDRN and PN significantly improved tendon healing, increased load to failure, and reduced fatty infiltration.
- The treatment also raised plasma levels of important growth factors, with PN demonstrating a longer-lasting effect compared to PDRN.
Article Abstract
Failure rate after chronic rotator cuff repair is considerably high. Moreover, diabetes mellitus is known as a compromising factor of rotator cuff tear. The effect of Polydeoxyribonucleotide (PDRN) and polynucleotide (PN) on tendon healing and fatty infiltration is unclear as tissue regeneration activator in diabetic state. Therefore, a diabetic rat model with chronic rotator cuff tear was made for mechanical, histologic and blood tests. In the animal study using a diabetic rat cuff repair model, the administration of PDRN and PN increased the load to failure of repaired cuffs and improved tendon healing and decreased fatty infiltration. Also, the plasma levels of vascular endothelial growth factor and fibroblast growth factor were elevated in PDRN and PN administrated groups. We concluded that PDRN and PN appear to boost tendon recovery and reduce the presence of fatty infiltration following cuff repair in diabetic state. Also, PN showed a later onset and a longer duration than PDRN associated with the mean plasma growth factors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375112 | PMC |
| http://dx.doi.org/10.1038/s41598-024-71206-8 | DOI Listing |
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