AI Article Synopsis
- Recent advancements have led to the development of premixed calcium silicate-based materials for various endodontic procedures, particularly vital pulp therapy.
- A study assessed the biocompatibility and mineralization effects of materials like EndoSequence Root Repair Material and Bio-C Repair, finding no harmful effects on human dental pulp stem cells.
- In vivo tests showed that these materials promoted mineralized tissue formation in exposed tooth pulps of rats after two weeks, suggesting their effectiveness for direct pulp capping.
Article Abstract
Premixed calcium silicate-based materials have recently been developed and are recommended for a wide range of endodontic procedures, including vital pulp therapy. This study investigated the in vitro biocompatibility and pro-mineralization effect and in vivo reparative dentin formation of EndoSequence Root Repair Material, EndoSequence BCRRM, Bio-C Repair, and Well-pulp PT. Both fresh and set extracts had no detrimental effect on the growth of human dental pulp stem cells. The fresh extracts had a higher calcium concentration than the set extracts and induced considerably greater mineralized nodule formation. EndoSequence Root Repair Material had the longest setting time, whereas Bio-C Repair had the shortest. When these materials were applied to exposed rat molar pulps, mineralized tissue deposition was found at the exposure sites after 2 weeks. These results indicate that the premixed calcium silicate-based materials tested could have positive benefits for direct pulp capping procedures.
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| http://dx.doi.org/10.4012/dmj.2024-121 | DOI Listing |
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