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Current practice and barriers for transition of care (TOC) in pediatric surgery: perspectives of adult surgeons from different subspecialties.
Pediatr Surg Int
January 2025
Department of Surgery, Sultanah Aminah Hospital, Jalan Persiaran Abu Bakar Sultan, 80100, Johor Bahru, Johor, Malaysia.
Introduction: The advancements in neonatal resuscitation and surgical care have enabled children with congenital abnormalities to receive corrective surgeries and achieve lifespans well into adulthood. These patients may require long-term follow-up as they continue to have risks of developing sequelae from their original diseases or surgical interventions.
Purpose: This study aimed to investigate the current practice and barriers to the transition of care (TOC) from the perspectives of adult surgeons.
Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction.
ACS Appl Mater Interfaces
January 2025
Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Splice-switching oligonucleotides (SSOs) can restore protein functionality in pathologies and are promising tools for manipulating the RNA-splicing machinery. Delivery vectors can considerably improve SSO functionality in vivo and allow dose reduction, thereby addressing the challenges of RNA-targeted therapeutics. Here, we report a biocompatible SSO nanocarrier, based on redox-responsive disulfide cross-linked low-molecular-weight linear polyethylenimine (cLPEI), for overcoming multiple biological barriers from subcellular compartments to en-route serum stability and finally in vivo delivery challenges.
View Article and Find Full Text PDFStay in the Game: Comprehensive Approaches to Decrease the Risk of Sports Injuries.
Cureus
December 2024
Physiotherapy and Physical Medicine, University of Dschang, Dschang, CMR.
Recurrent sports injuries present complex challenges that extend beyond the playing field, impacting athletes' physical well-being, mental resilience, and financial stability. This review outlines a comprehensive framework designed to prevent and manage these setbacks, empowering athletes to achieve sustained performance and recovery. This multidimensional issue requires an integrative approach encompassing physical rehabilitation, psychological resilience, and nutritional strategies.
View Article and Find Full Text PDFResident Experiences at a Community Hospital Caring for Patients Who Are Incarcerated.
J Correct Health Care
January 2025
Department of Obstetrics and Gynecology, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
There is no standardized curriculum that teaches medical residents to navigate the ethical and logistical complexities of bedside care delivery to patients who are incarcerated. In this article, we describe resident physician bedside experiences at a community teaching hospital caring for patients who are incarcerated. From 2022 to 2023, residents in emergency medicine, general surgery, internal medicine, and obstetrics and gynecology were offered an anonymous survey, self-administered via REDCap software, to explore their experiences caring for this patient population.
View Article and Find Full Text PDFPredicting preventive self-care behaviours among type 2 diabetes based on the health belief model in Bandar Abbas city: a cross-sectional study.
BMJ Open
January 2025
Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Objectives: It is essential to manage type 2 diabetes mellitus (T2DM) through self-care behaviours and to ascertain the predictors of correct health training for the control of diabetes. The aim of this study was to determine the predictive role of the constructs of the health belief model in encouraging T2DM to adopt self-care behaviours in Bandar Abbas city.
Design: This cross-sectional study was conducted in 2022 in Bandar Abbas.
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