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Acute Leukemia Diagnosis Through AI-Enhanced Attenuated Total Reflection Fourier Transform Infrared Spectroscopy of Peripheral Blood Smears.
Appl Spectrosc
December 2024
The Graduate School, University of Santo Tomas, Manila, Philippines.
Acute leukemia, a highly perilous cancer, is diagnosed using invasive procedures like bone marrow aspirate and biopsy (BMA/BMB). This study investigated the use of artificial intelligence (AI)-enhanced Fourier transform infrared (FT-IR) spectroscopy as a non-invasive, reagent-free diagnostic alternative with high sensitivity and specificity. The spectral peak patterns of peripheral blood smears (PBS) from clinically healthy individuals ( = 50) BMA/BMB-confirmed acute leukemia patients ( = 50) were examined in the 1800-850 cm range.
View Article and Find Full Text PDFUtility of Multiparametric Prostate MRI to Predict Regional or Distant Metastatic Disease Against Conventional Staging Using CT and Bone Scintigraphy or 68Ga-PSMA PET in Intermediate-to-High-Risk Prostate Cancer.
Cureus
November 2024
Department of Urology, Western Health, Melbourne, AUS.
Background: Multiparametric magnetic resonance imaging (mpMRI) is now the standard of care to guide prostate biopsies during workups and assessment of men with suspected prostate cancer (PCa). In addition to intraprostatic lesion detection, MRI usually covers the bony pelvis and pelvic lymph nodes, two of the commonest sites for metastatic disease. Subsequent staging has traditionally been based on further scanning using a combination of computed tomography (CT) and bone scintigraphy (BS), and more recently, positron emission tomography (PET) scanning with prostate-specific membrane antigen (PSMA) ligand.
View Article and Find Full Text PDFA New Diagnostic Approach for Myelodysplastic Neoplasms Using a Combination of Scores Based on Flow Cytometry and Automated Hematology Sysmex XN Analyzers.
Int J Lab Hematol
December 2024
Laboratory of Hematology, Hospital Group of Lille Catholic University, Lille, France.
Introduction: The first-step in diagnosis of myelodysplastic neoplasms (MDS) is essentially based on bone marrow cytomorphology. However, cytomorphology of MDS is often a difficult exercise, subject to inter-operator variability. Our study aims to evaluate whether the combination of two dysplasia scores, the extended Ogata score and the MDS-CBC score, could improve the screening of MDS patients among patients with chronic cytopenia.
View Article and Find Full Text PDFValidation of American College of Radiology Bone Reporting and Data System (Bone-RADS) Version 2023 for diagnosis of malignant tumors of appendicular bone on conventional radiographs.
Eur J Radiol
November 2024
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Purpose: To evaluate the diagnostic performance of the American College of Radiology(ACR) Bone Reporting and Data System (Bone-RADS) in diagnosis of malignant tumors of the appendicular bone on conventional radiographs.
Methods: Primary and secondary tumors of appendicular bone in patients who underwent radiographic and MRI examinations were classified into benign, intermediate, and malignant using a reference standard of histopathology, imaging follow-up, or clinical-radiologic consensus. Two radiologists assessed five radiographic features (margin, periosteal reaction, endosteal erosion, pathologic fracture, and extra-osseous mass), scored point total (points from radiographic features and a history of cancer), and assigned Bone-RADS categories.
Diagnostic performance of spectral CT in detecting bone marrow edema for vertebral fracture: A multi-reader study.
Eur J Radiol
January 2025
University Hospital of Dijon, Department of Diagnostic and Therapeutic Neuroradiology, 14 boulevard Gaffarel, 21000 Dijon, France.
Background And Purpose: To evaluate the spectral scanner (Aquilion One PRISM Edition, Canon Medical Systems Corporation, Otawara, Japan) diagnostic performance to identify bone marrow edema (BME) in vertebrae of patients managed for suspected vertebral compression fracture in the emergency department of Dijon University Hospital.
Methods: 14 consecutive patients underwent spectral imaging and MRI spinal imaging, from January 2023 to March 2024 were retrospectively analyzed. 85 vertebrae were assessed for the detection of fracture on conventional CT images and the presence of bone marrow edema (BME) in all vertebral bodies on VNCa mapping for both Bone and Research preset, who was judged to indicate a fresh fracture.
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