AI Article Synopsis
- Advanced bioinformatics methods, particularly systems biology (SysBio) and artificial intelligence (AI), are increasingly utilized in stem cell research, showing significant growth in global research output from 2000 to 2021.
- A notable 10-fold increase in AI-related research has occurred since 2010, reflecting a trend towards integrating AI tools in preclinical and translational medicine.
- The United States and the United Kingdom lead in both SysBio and AI-related publications, highlighting a global evolution and strengthening relationship among these fields in stem cell research over the last 20 years.
Article Abstract
Advanced bioinformatics analysis, such as systems biology (SysBio) and artificial intelligence (AI) approaches, including machine learning (ML) and deep learning (DL), is increasingly present in stem cell (SC) research. An approximate timeline on these developments and their global impact is still lacking. We conducted a scoping review on the contribution of SysBio and AI analysis to SC research and therapy development based on literature published in PubMed between 2000 and 2024. We identified an 8 to 10-fold increase in research output related to all 3 search terms between 2000 and 2021, with a 10-fold increase in AI-related production since 2010. Use of SysBio and AI still predominates in preclinical basic research with increasing use in clinically oriented translational medicine since 2010. SysBio- and AI-related research was found all over the globe, with SysBio output led by the (US, n = 1487), (UK, n = 1094), Germany (n = 355), The Netherlands (n = 339), Russia (n = 215), and France (n = 149), while for AI-related research the US (n = 853) and UK (n = 258) take a strong lead, followed by Switzerland (n = 69), The Netherlands (n = 37), and Germany (n = 19). The US and UK are most active in SCs publications related to AI/ML and AI/DL. The prominent use of SysBio in ESC research was recently overtaken by prominent use of AI in iPSC and MSC research. This study reveals the global evolution and growing intersection among AI, SysBio, and SC research over the past 2 decades, with substantial growth in all 3 fields and exponential increases in AI-related research in the past decade.
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| http://dx.doi.org/10.1093/stmcls/sxae054 | DOI Listing |
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