A highly regioselective and enantioselective transfer hydrogenation of pyrano[2,3-]indoles with Hantzsch ester has been successfully realized using spiro-chiral phosphoric acid, affording a series of optically active 1,4-reductive adducts, 4,9-dihydropyrano[2,3-]indoles, in 34-99% yields with 61-99% .
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| http://dx.doi.org/10.1021/acs.orglett.4c02385 | DOI Listing |
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