AI Article Synopsis
- Recent research has focused on drug delivery systems to improve efficiency and reduce toxicity, particularly highlighting oral patches and films for their convenience and effectiveness.
- These systems can bypass the liver's metabolism, increasing drug availability and promoting better patient compliance, especially for those with specific needs.
- The review discusses design, manufacturing, and research methods for oral patches/films, their applications in targeted and systemic delivery, and offers future perspectives on advancing oral localized drug delivery systems.
Article Abstract
In recent years, there has been extensive research into drug delivery systems aimed at enhancing drug utilization while minimizing drug toxicities. Among these systems, oral patches/films have garnered significant attention due to their convenience, noninvasive administration, ability to bypass hepatic first-pass metabolism, thereby enhancing drug bioavailability, and their potential to ensure good compliance, particularly among special patient populations. In this review, from the perspective of the anatomical characteristics of the oral cavity and the advantages and difficulties of oral drug delivery, we illustrate the design ideas, manufacturing techniques, research methodologies, and the essential attributes of an ideal oral patch/film. Furthermore, the applications of oral patches/films in both localized and systemic drug delivery were discussed. Finally, we offer insights into the future prospects of the oral patch/film, aiming to provide valuable reference for the advancement of oral localized drug delivery systems.
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| http://dx.doi.org/10.1002/bip.23625 | DOI Listing |
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