To evaluate the prevalence of TTR amyloid cardiomyopathy (ATTR-CM) in severe aortic stenosis (SAS) patients, and to determine the independent predictors of major adverse events (MAE). 91 SAS patients >65 years with an interventricular septum thickness ≥12.5 mm were referred for aortic valve replacement (AVR). 99mTc-DPD scintigraphy was applied to diagnose ATTR-CM, in the absence of monoclonal protein. ATTR-CM was found in 11%. 78% of patients underwent AVR, but only 2 had ATTR-CM. There were no significant differences in the composite of all cause-mortality or cardiovascular hospitalizations. Lower left ventricle ejection fraction and not performing AVR were independent predictors of MAE. Not performing AVR was an independent predictor of MAE, regardless the ATTR-CM diagnosis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457626PMC
http://dx.doi.org/10.1080/14796678.2024.2393031DOI Listing

Publication Analysis

Top Keywords

amyloid cardiomyopathy
8
severe aortic
8
aortic stenosis
8
valve replacement
8
sas patients
8
independent predictors
8
performing avr
8
avr independent
8
transthyretin amyloid
4
cardiomyopathy severe
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!