Background: Gastrodin is the active monomer of the Chinese herb Rhizoma Gastrodiae with the largest quantity of active components. Gastrodin is commonly used in the treatment of central nervous system disorders such as headaches and epilepsy due to its sedating and hypnotic properties. Its pharmacological mechanism and clinical application have been extensively explored due to its low toxicity.
Methods: To investigate the molecular mechanism of hepatic uptake of Gastrodin in rats, animals were randomly assigned to three groups: control group, rifampicin (RIF) group, and adrenalone (ADR) group. Blood samples were collected through the cardiac puncture 90, 180, and 300 min after injection, respectively. Rats were sacrificed 300 min after administration, and liver tissue was collected. Gastrodin concentration was determined by HPLC, and the Kp value was calculated.
Results: After administering the inhibitors of organic cation transporters (OCTs) and organic anion transporting polypeptides (OATPs), the K values in the experimental groups were significantly lower compared to the blank control group (P < 0.05).
Conclusions: These findings imply that Gastrodin may be a substrate for both OCTs and OATPs.
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| http://dx.doi.org/10.1016/j.heliyon.2024.e36031 | DOI Listing |
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In this study, multivesicular liposomes (MVLs) were prepared by microfluidic technology and used for delivering gastrodin (GAS), a water-soluble drug, across the blood-brain barrier (BBB). The formulations and preparation parameters in preparing gastrodin multivesicular liposomes (GAS-MVLs) were both optimized. Some properties of GAS-MVLs including morphology, particle size, encapsulation efficiency, and release were evaluated.
View Article and Find Full Text PDFStudy on the uptake of Gastrodin in the liver.
Heliyon
August 2024
School of Life Science and Engineering, Southwest Jiaotong University, No. 111, Chengdu North 2nd Ring Road, Chengdu, Sichuan, 610003, China.
Background: Gastrodin is the active monomer of the Chinese herb Rhizoma Gastrodiae with the largest quantity of active components. Gastrodin is commonly used in the treatment of central nervous system disorders such as headaches and epilepsy due to its sedating and hypnotic properties. Its pharmacological mechanism and clinical application have been extensively explored due to its low toxicity.
View Article and Find Full Text PDFPreparation of gastrodin-modified dendrimer-entrapped gold nanoparticles as a drug delivery system for cerebral ischemia-reperfusion injury.
Brain Behav
December 2022
Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Objective: This study sought to evaluate the feasibility of multifunctional gastrodin (GAS)-containing nano-drug carrier system against cerebral ischemia-reperfusion injury (CIRI).
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Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.
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School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing, China.
As a severe metabolic disease, type 2 diabetes mellitus (T2DM) has become a serious threat to human health in recent years. Gastrodin, as a primary chemical constituent in Gastrodia elata Blume, has antidiabetic effects. However, the possible mechanisms are unclear.
View Article and Find Full Text PDFThe transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells.
Yao Xue Xue Bao
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The Second Hospital of Wuxi, Wuxi 214002, China.
Gastrodin (GAS) is the major bioactive component of the extracts from the rhizome of Gastrodia elata Blume. The aim of this study is to investigate the transport of GAS in Caco-2 cells and the interaction of P-glycoprotein and GAS. The apparent permeability coefficients (Papp) of GAS were measured as a function of directions and concentrations.
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