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http://dx.doi.org/10.1093/ehjimp/qyae083DOI Listing

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Article Synopsis
  • The study evaluates various techniques for guiding percutaneous coronary intervention (PCI) to determine which yields the best patient outcomes.
  • It analyzes data from 39 randomized trials involving over 29,000 patients, highlighting that intravascular imaging (like OCT and IVUS) and physiology-guided strategies (like FFR) significantly reduce cardiac death compared to traditional coronary angiography (CA).
  • Overall, the results suggest that OCT is the most effective guidance method, leading to lower rates of myocardial infarction, stent thrombosis, and all-cause mortality compared to CA.
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Background: The role of Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) is still unclear in patients with STEMI undergoing PCI in the current second-generation DES era.

Aims: This study aimed to evaluate the trends and outcomes of IVUS-guided PCI in patients with STEMI.

Methods: We used the National Inpatient Sample (NIS) database from 2016 to 2021.

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Limited evidence exists regarding the long-term outcomes of true versus nontrue coronary bifurcation lesions (CBLs) treated with current-generation drug-eluting stents and intravascular imaging guidance. The Sapporo Cardiovascular Clinic (SCVC) registry was a prospective, single-center, all-comers registry enrolling 1,727 consecutive patients treated with bioresorbable polymer sirolimus-eluting stent under complete imaging guidance. From this registry, 440 patients with CBLs (25.

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Brucellosis is an infectious disease caused by bacteria of the genus , predominantly affecting livestock and humans through contact or consumption. It is a major public health challenge, particularly in developing countries. Symptoms can be mild to severe, making diagnosis difficult and often resulting in more chronic problems if those issues are not addressed.

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Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking nanoparticles for fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma.

J Nanobiotechnology

December 2024

School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.

Cyanine dye-containing nanoparticles have widely been used in "all-in-one" NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modulation methods to tune absorption and emission wavelengths. The combination of good brightness and excellent tumor-targeting capacity is the key to realize efficient NIR-II FI-guided PTT. In this study, by covalently decorating NIR-II absorptive cyanine dyes with bulky AIE motify, we demonstrate how steric hindrance suppresses π-π stacking-induced fluorescence quenching and contributes to the good brightness of NIR-II FI of subcutaneous glioblastoma.

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