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| http://dx.doi.org/10.3389/fimmu.2024.1474042 | DOI Listing |
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O-GlcNAcylation dictates pyroptosis.
Front Immunol
January 2025
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Article Synopsis
- O-GlcNAcylation is a modification that adds a sugar molecule, N-acetylglucosamine, to specific amino acids, influencing signaling pathways important for pyroptosis, a form of cell death.
- Enhancing O-GlcNAcylation of the protein GSDMD is suggested as a key strategy for improving blood flow issues in sepsis, while GSDME's role in macrophage pyroptosis is linked to high glucose levels in periodontitis.
- The review discusses O-GlcNAcylation's impact on the NLRP3 inflammasome and other regulators, highlighting its potential as a therapeutic target for diseases like sepsis and osteoarthritis by managing inflammation.
Editorial: O-GlcNAcylation and the immune system.
Front Immunol
September 2024
Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
O-GlcNAc impacts mitophagy via the PINK1-dependent pathway.
Front Aging Neurosci
August 2024
School of Medicine, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS, United States.
Background: The accumulation of dysfunctional mitochondria is an early feature of Alzheimer's disease (AD). The impaired turnover of damaged mitochondria increases reactive oxygen species production and lowers ATP generation, leading to cellular toxicity and neurodegeneration. Interestingly, AD exhibits a disruption in the global post-translational modification β-N-acetylglucosamine (O-GlcNAc).
View Article and Find Full Text PDFSingle cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells.
Front Immunol
April 2024
Department of Pathology, Case Western Reserve University, Cleveland, OH, United States.
Introduction: Acute myeloid leukemia (AML) is the most common acute leukemia in adults with an overall poor prognosis and high relapse rate. Multiple factors including genetic abnormalities, differentiation defects and altered cellular metabolism contribute to AML development and progression. Though the roles of oxidative phosphorylation and glycolysis are defined in AML, the role of the hexosamine biosynthetic pathway (HBP), which regulates the O-GlcNAcylation of cytoplasmic and nuclear proteins, remains poorly defined.
View Article and Find Full Text PDFO-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells.
World J Stem Cells
March 2024
Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China.
Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.
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