AI Article Synopsis
- - Women have a higher prevalence of tricuspid regurgitation (TR) and tend to present with more advanced stages of the condition compared to men, leading to the exploration of sex-based differences in eligibility for transcatheter tricuspid valve interventions (TTVI).
- - A study of 569 patients revealed that while men exhibited more left ventricular dysfunction and heart failure signs, women were more likely to experience isolated TR and TR linked to severe pulmonary hypertension.
- - Despite differences in presenting conditions, the majority of patients were not eligible for TTVI, and sex did not significantly impact eligibility for the procedure.
Article Abstract
Background: Women have a higher prevalence of tricuspid regurgitation (TR) and present at more advanced stages as compared with men. Given the high operative mortality associated with tricuspid valve (TV) surgery, transcatheter tricuspid valve interventions (TTVI) have emerged as a promising treatment option. We explored sex-based differences among patients with significant TR who would be expected to be eligible for TTVI.
Methods: Between March 2021-2022, 12,677 unique adult patients underwent a transthoracic echocardiogram at our tertiary care institution. Clinical and echocardiographic data were collected for patients with more than moderate TR. The 2021 European Society of Cardiology valve guidelines were used to retrospectively define sub-populations who would have been eligible for TTVI, TV surgery, or medical therapy. Patients were grouped by sex and compared using t-tests, Wilcoxon rank-sum, Pearson chi-square, and Cox regression for survival analysis.
Results: Of 569 patients, 52% (296/569) were female. Men had a higher prevalence of left ventricular dysfunction (p < 0.001), mitral regurgitation (p = 0.023), and signs of heart failure (New York Heart Association stage III (p = 0.031)). Women had more isolated TR (p = 0.020) and TR due to severe pulmonary hypertension (p < 0.001). Most patients (74.6% of women, 76.9% of men) were precluded from both transcatheter and surgical intervention due to advanced disease. 10.8% of women and 9.2% of men would have qualified for TTVI (p = 0.511).
Conclusion: The majority of patients with significant TR presenting to a tertiary care center are not eligible for TTVI. Sex is not a predictor of eligibility for TTVI among patients with significant TR.
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| http://dx.doi.org/10.1002/ccd.31216 | DOI Listing |
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