AI Article Synopsis
- The introduction of thrombopoietin mimetics, like romiplostim and eltrombopag, has significantly changed how pediatric immune thrombocytopenia is treated.
- Dosing for eltrombopag varies based on patient age, liver function, and ethnicity, but similar doses can lead to different side effects and platelet counts among children.
- There is a hypothesis that the varying levels of eltrombopag in the bloodstream may be influencing these different responses to the medication.
Article Abstract
Paediatric immune thrombocytopenia treatment was revolutionized with the advent of the thrombopoietin mimetics romiplostim and eltrombopag. For eltrombopag, dosing recommendations have been based on patients' ages (with dose reductions for those with hepatic impairment and for some of East Asian ethnicity) and titrated based on platelet counts and adverse drug reactions. However, it is clear that identical eltrombopag dosing for paediatric patients can result in variable side effects and platelet counts, raising the question as to whether variable eltrombopag plasma concentrations are responsible for these differing drug responses. Commentary on: Dong et al. Exploratory study on the individualized application of eltrombopag in paediatric immune thrombocytopenia guided by therapeutic drug monitoring. Br J Haematol 2024; 205:1930-1937.
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| http://dx.doi.org/10.1111/bjh.19757 | DOI Listing |
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