AI Article Synopsis
- * BPD may develop due to unusual repair responses from lung injuries that happen either before or after birth, with intrauterine inflammation identified as a key risk factor for these injuries and their connection to BPD.
- * The review explores research on how intrauterine inflammation impacts lung development, particularly the formation of alveoli and blood vessels, while also considering prenatal treatment strategies aimed at reducing this inflammation to prevent or manage BPD.
Article Abstract
Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in infants and the most frequent adverse outcome of premature birth, despite major efforts to minimize injury. It is thought to result from aberrant repair response triggered by either prenatal or recurrent postnatal injury to the lungs during development. Intrauterine inflammation is an important risk factor for prenatal lung injury, which is also increasingly linked to BPD. However, the specific mechanisms remain unclear. This review summarizes clinical and animal research linking intrauterine inflammation to BPD. We assess how intrauterine inflammation affects lung alveolarization and vascular development. In addition, we discuss prenatal therapeutic strategies targeting intrauterine inflammation to prevent or treat BPD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373297 | PMC |
| http://dx.doi.org/10.1186/s10020-024-00909-5 | DOI Listing |
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