AI Article Synopsis
- lncRNA, specifically HIF1A-AS2, is found to be upregulated in colorectal cancer (CRC) tissues, linking it to poor patient outcomes and tumor development.
- HIF1A-AS2 promotes cancer cell proliferation, metastasis, and a shift to aerobic glycolysis by influencing the expression of FOXC1 through direct interaction with miR-141-3p.
- The study suggests that HIF1A-AS2, regulated by SP1 and also packaged in exosomes, could serve as a valuable diagnostic marker and a potential target for CRC treatments.
Article Abstract
lncRNA can regulate tumorigenesis development and distant metastasis of colorectal cancer (CRC). However, the detailed molecular mechanisms are still largely unknown. Using RNA-sequencing data, RT-qPCR, and FISH assay, we found that HIF1A-AS2 was upregulated in CRC tissues and associated with poor prognosis. Functional experiments were performed to determine the roles of HIF1A-AS2 in tumor progression and we found that HIF1A-AS2 can promote the proliferation, metastasis, and aerobic glycolysis of CRC cells. Mechanistically, HIF1A-AS2 can promote FOXC1 expression by sponging miR-141-3p. SP1 can transcriptionally activate HIF1A-AS2. Further, HIF1A-AS2 can be packaged into exosomes and promote the malignant phenotype of recipient tumor cells. Taken together, we discovered that SP1-induced HIF1A-AS2 can promote the metabolic reprogramming and progression of CRC via miR-141-3p/FOXC1 axis. HIF1A-AS2 is a promising diagnostic marker and treatment target in CRC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372083 | PMC |
| http://dx.doi.org/10.1038/s41419-024-06958-2 | DOI Listing |
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