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[The modifying cytogenetic effects of gossypol and its derivatives].
Izv Akad Nauk Ser Biol
January 1995
The method of micronuclei account allowed to demonstrate protective effect of gossypol and its derivatives megacin and batriden of chromosomes of rat male germ cells from mutagenic effect of nitrosomethylurea (NMU) and, conversely, enhancement of clastogenic effect of another alkylating agent, fotrin. Strong antimutagenic effect of gossypol from NMU was also observed in external granular layer of young rat cerebellum. Possible mechanisms of antimutagenic action of this unique polyphenol of cotton plant are discussed.
View Article and Find Full Text PDFAnthrax-specific "AP 50-like" phages isolated from Bacillus cereus strains.
Acta Microbiol Acad Sci Hung
December 1982
Article Synopsis
- Scientists isolated phages targeting Bacillus anthracis from lysates of Bacillus cereus strains that produce megacin A.
- The new phages exhibited similarities to the previously identified anthrax-specific phage AP 50 in terms of structure, host range, and sensitivity to various chemicals.
- DNA analysis confirmed the unique nature of AP 50, indicating that it and similar phages form a distinct group affecting Bacillus strains.
Five out of a number of Bacillus cereus strains isolated from soil produced high titre specific bacteriocin (megacin A) in mitomycin C-induced cultures. In the course of cultivation with ethidium bromide, the strains gave off segregants not producing bacteriocin (cin-). The lysate of two wild strains formed plaques on the corresponding cin- bacteria.
View Article and Find Full Text PDFElectron microscopy of phages liberated by megacin A producing lysogenic Bacillus megaterium strains.
Acta Microbiol Acad Sci Hung
April 1975
Mitomycin C was added at fairly high concentration (5-10 mug/ml) to exponentially growing cultures of selected strains of Bacillus megaterium. Lysis of the bacteria followed, associated by liberation of phage and megacin A production. In contrast, a low concentration (0.
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