AI Article Synopsis
- - This study creates a model to explore how a cytokine storm, caused by viral infections, leads to demyelination and affects neuron behavior, especially regarding action potential signal propagation.
- - By applying information and communication theory, the researchers examine how demyelination alters neuron-to-neuron communication, indicating that virus-induced degeneration impacts signal strength and firing rates.
- - The findings suggest that demyelination not only weakens the action potential signals but also disrupts their travel along the axon, helping to enhance knowledge of neurodegeneration linked to viral infections.
Article Abstract
In this study, we develop an model of a neuron's behaviour under demyelination caused by a cytokine storm to investigate the effects of viral infections in the brain. We use a comprehensive model to measure how cytokine-induced demyelination affects the propagation of action potential (AP) signals within a neuron. We analysed the effects of neuron-neuron communications by applying information and communication theory at different levels of demyelination. Our simulations demonstrate that virus-induced degeneration can play a role in the signal power and spiking rate, which compromise the propagation and processing of information between neurons. We propose a transfer function to model the weakening effects on the AP. Our results show that demyelination induced by a cytokine storm not only degrades the signal but also impairs its propagation within the axon. Our proposed model can analyse virus-induced neurodegeneration and enhance our understanding of virus-induced demyelination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371429 | PMC |
| http://dx.doi.org/10.1098/rsob.240138 | DOI Listing |
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