AI Article Synopsis
- - The study assessed the cost-effectiveness of extended postoperative antibiotic prophylaxis (E-PAP) following adult spinal surgeries.
- - Both types of analysis (stratified and nonstratified) showed E-PAP did not significantly reduce surgical site infections (SSI) compared to standard protocols.
- - Implementing E-PAP resulted in longer hospital stays and higher costs, with increases of $244.4 for the 72-hour protocol and $309.8 for the >48 hours protocol compared to shorter antibiotic treatments.
Article Abstract
» We aimed to determine the cost-effectiveness of different protocols of extended postoperative antibiotic prophylaxis (E-PAP) following adult spinal surgery. » Both stratified (randomized controlled trials only) and nonstratified (all studies) analyses demonstrated that E-PAP has no significant value in reducing the rate of surgical site infection (SSI), deep SSI, or superficial SSI. » Notably, the E-PAP protocols were associated with a significant increase in the length of hospital stay, resulting in an additional expenditure of $244.4 per episode for the E-PAP 72 hours protocol compared with PAP 24 hours and $309.8 per episode for the E-PAP >48 hours protocol compared with PAP <48 hours. » E-PAP does not demonstrate any significant reduction in the rate of SSIs following spine surgery. However, these extended protocols were significantly associated with an increase in the length of hospital stay and higher overall projected costs.
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| http://dx.doi.org/10.2106/JBJS.RVW.24.00068 | DOI Listing |
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