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Heterologous expression of lasso peptides with apparent participation in the morphological development in Streptomyces. | LitMetric

Heterologous expression of lasso peptides with apparent participation in the morphological development in Streptomyces.

AMB Express

Departamento de Biología Molecular y Biotecnología del Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), 04510, CdMx, Mexico.

Published: September 2024

AI Article Synopsis

Article Abstract

Lasso peptides, ribosomally synthesized and post-translationally modified peptides, are primarily produced by bacteria and some archaea. Streptomyces lasso peptides have been known for their antimicrobial, anticancer, and antiviral properties. However, understanding their role in the morphology and production of secondary metabolites remains limited. We identified a previously unknown lasso peptide gene cluster in the genome of Streptomyces sp. L06. This gene cluster (LASS) produces two distinct lasso peptides, morphosin-1 and - 2. Notably, morphosin-2 is a member of a new subfamily of lasso peptides, with BGCs exhibiting a similar structure. When LASS was expressed in different Streptomyces hosts, it led to exciting phenotypic changes, including the absence of spores and damage in aerial mycelium development. In one of the hosts, LASS even triggered antibiotic formation. These findings open up a world of possibilities, suggesting the potential role of morphosins in shaping Streptomyces' morphological and biochemical development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371967PMC
http://dx.doi.org/10.1186/s13568-024-01761-wDOI Listing

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