AI Article Synopsis
- The study explores how changes in gut microbiota might influence slow-transit constipation (STC), focusing on a comparison between STC patients and healthy controls.
- Researchers analyzed the gut microbiota of 24 STC patients and 24 matched controls using advanced metagenomic techniques, revealing significant differences in the composition of gut bacteria between the two groups.
- Key findings indicate that specific bacteria like Gordonibacter pamelaeae and Bifidobacterium longum are more prevalent in STC patients, while others like Coprococcus comes are found more in controls, suggesting a distinct microbial and metabolic profile related to STC.
Article Abstract
Introduction: Altered gut microbiota may play a role in slow-transit constipation (STC). We conducted a study of gut microbiota composition and functionality in STC using metagenomic analyses.
Methods: We assembled a clinical cohort of 24 patients with STC physiology age- and sex-matched to 24 controls. We performed shotgun metagenomic sequencing followed by prediction of metabolite composition from functional profiles.
Results: In a middle-aged (mean 55.3 years), predominantly female cohort, there were no significant differences in α-diversity indices, but permutational multivariate analysis of variance analysis showed significant between-group differences (R 2 = 0.050, P < 0.001) between STC patients and controls. Gordonibacter pamelaeae , Bifidobacterium longum , Firmicutes bacterium co-abundance gene group 94, and Anaerotruncus colihominis were more abundant in STC, whereas Coprococcus comes and Roseburia intestinalis were more abundant in controls. Gut-derived metabolites varying in STC relative to controls were related to bile acid and cholesterol metabolism.
Discussion: We found a unique metagenomic and metabolomic signature of STC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11500773 | PMC |
| http://dx.doi.org/10.14309/ctg.0000000000000766 | DOI Listing |
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