AI Article Synopsis
- - Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer that arises after advanced treatments, marked by the loss of androgen receptor signaling and rapid progression.
- - The third symposium on NEPC, held in June 2024 in Canada, brought together leading researchers and clinicians to discuss recent advancements, molecular pathways, and innovative treatment strategies.
- - Experts emphasized the need for early detection and personalized medicine to tackle NEPC, highlighting the importance of global collaboration to improve understanding and treatment of this complex disease.
Article Abstract
Neuroendocrine prostate cancer (NEPC) is a rare and aggressive subtype of prostate cancer (PCa), emerging from advanced treatments and characterized by loss of androgen receptor (AR) signaling and neuroendocrine features, leading to rapid progression and treatment resistance. The third symposium on treatment-induced NEPC, held from 21 to 23 June 2024, at Harrison Hot Springs Resort, BC, Canada, united leading global researchers and clinicians. Sponsored by the Vancouver Prostate Centre (VPC), Canadian Institute of Health Research, Prostate Cancer Foundation Canada and Pharma Planter Inc, the event focused on the latest NEPC research and innovative treatment strategies. Co-chaired by Drs. Yuzhuo Wang and Martin Gleave, the symposium featured sessions on NEPC's historical context, molecular pathways, epigenetic regulation and the role of the tumor microenvironment and metabolism in its progression. Keynotes from experts like Dr. Himisha Beltran and Dr. Martin Gleave highlighted the complexity of NEPC. The Emerging Talent session showcased new research, pointing to the future of NEPC treatment. The symposium concluded with a consensus on the need for early detection, targeted therapies and personalized medicine to effectively combat NEPC, emphasizing the importance of global collaboration in advancing NEPC understanding and treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457638 | PMC |
| http://dx.doi.org/10.1080/17501911.2024.2391729 | DOI Listing |
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