AI Article Synopsis
- T1 mapping and Quantitative Susceptibility Mapping (QSM) are being studied as methods to measure changes in knee osteoarthritis, focusing on their effectiveness in analysis of articular cartilage.* -
- The study involved 20 healthy participants who underwent MRI with different spin lock times, aiming to assess how these combinations impact T1 estimation and correlate with QSM data.* -
- Results showed longer T1 times with higher spin lock periods and noted significant depth-specific differences in both T1 and QSM, suggesting these methods together can enhance the understanding of cartilage microstructure changes.*
Article Abstract
Unlabelled: T1 and Quantitative Susceptibility Mapping (QSM) are evolving as substrates for quantifying the progressive nature of knee osteoarthritis.
Objective: To evaluate the effects of spin lock time combinations on depth-dependent T1 estimation, in adjunct to QSM, and characterize the degree of shared variance in QSM and T1 for the quantitative measurement of articular cartilage.
Design: Twenty healthy participants (10 M/10F, 22.2 ± 3.4 years) underwent bilateral knee MRI using T1 MAPPS sequences with varying TSLs ([0-120] ms), along with a 3D spoiled gradient echo for QSM. Five total TSL combinations were used for T1 computation, and direct depth-based comparison. Depth-wide variance was assessed in comparison to QSM as a basis to assess for depth-specific variation in T1 computations across healthy cartilage.
Results: Longer T1 relaxation times were observed for TSL combinations with higher spin lock times. Depth-specific differences were documented for both QSM and T1 , with most change found at ∼60% depth of the cartilage, relative to the surface. Direct squared linear correlation revealed that most T1 TSL combinations can explain over 30% of the variability in QSM, suggesting inherent shared sensitivity to cartilage microstructure.
Conclusions: T1 mapping is subjective to the spin lock time combinations used for computation of relaxation times. When paired with QSM, both similarities and differences in signal sensitivity may be complementary to capture depth-wide changes in articular cartilage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367491 | PMC |
| http://dx.doi.org/10.1016/j.ocarto.2024.100509 | DOI Listing |
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