AI Article Synopsis
- Mycoplasma pneumoniae pneumonia (MPP) accounts for a significant portion of pneumonia cases in children and is on the rise, prompting research into the role of miR-34a in diagnosis and recovery.
- The study utilized RT-qPCR to measure miR-34a levels and assessed its clinical relevance through ROC analysis, while also measuring inflammatory markers in the children's serum.
- Findings revealed that elevated miR-34a levels correlate with more severe MPP symptoms and a poorer recovery, indicating its potential as a diagnostic marker and a predictor of rehabilitation in affected children.
Article Abstract
Background: Mycoplasma pneumoniae pneumonia (MPP) is responsible for 20 to 40% of all cases of pneumonia acquired by children and shows an increasing incidence year by year. The aim of this study was to investigate the expression of miR-34a in children with MPP and its diagnostic value, and further explore the relationship between miR-34a and the rehabilitation effect of children with MPP.
Methods: The expression level of miR-34a was detected by RT-qPCR, and the clinical value of miR-34a was analyzed by ROC analysis. In addition, the levels of IL-6, IL-18 and TNF-α in serum of children with MPP were detected by ELISA kit, and the correlation with miR-34a was analyzed.
Results: Elevated levels of miR-34a were observed in the serum of children with MPP, and significantly higher expression levels were observed in children with severe symptoms and poor rehabilitation. The study suggested that miR-34a has potential as a diagnostic marker for MPP in children, helping to distinguish between mild and severe cases and predicting rehabilitation from MPP in children. In addition, miR-34a expression was positively correlated with IL-6, IL-8, and TNF-α levels.
Conclusions: miR-34a is closely related to MPP in children and miR-34a may be used as a clinical biomarker for MPP in children.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367975 | PMC |
| http://dx.doi.org/10.1186/s13019-024-02992-5 | DOI Listing |
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