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Activating the dark genome to illuminate cancer vaccine targets. | LitMetric

Activating the dark genome to illuminate cancer vaccine targets.

Nat Genet

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

Published: September 2024

AI Article Synopsis

Article Abstract

Epigenetic therapy awakens myriad transposable elements to generate new antigens that could prime tumor cells for immunotherapy. A new study of glioblastoma discovers indiscriminate awakening in normal cells also and then presents a more selective strategy for potential therapeutic targeting.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456370PMC
http://dx.doi.org/10.1038/s41588-024-01850-3DOI Listing

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