Anisotropic gold nanoparticles (AuNPs) are renowned for their unique properties - including localized surface plasmon resonance (LSPR) and adjustable optical responses to light exposure - that enable the conversion of light into heat and make them a promising tool in cancer therapy. Nonetheless, their tendency to aggregate and consequently lose their photothermal conversion capacity during prolonged irradiation periods represents a central challenge in developing anisotropic AuNPs for clinical use. To overcome this issue, an innovative approach that facilitates the encapsulation of individual anisotropic AuNPs within thin nanogels, forming hybrid nanomaterials that mirror the inorganic core's morphology while introducing a negligible (2-8 nm) increase in overall diameter is proposed. The encapsulation of rod- and star-shaped anisotropic AuNPs within poly-acrylamide (pAA) or poly-(N-isopropylacrylamide) (pNIPAM) nanogels is successfully demonstrated. The ultrathin polymeric layers display remarkable durability, significantly enhancing the photothermal stability of anisotropic AuNPs during their interaction with near-infrared light and effectively boosting their photothermal capacities for extended irradiation periods. The outcomes of the research thus support the development of more stable and reliable AuNPs as hybrid nanomaterials, positioning them as promising nanomedicinal platforms.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600699 | PMC |
| http://dx.doi.org/10.1002/smll.202404097 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Manipulating Near-Infrared Absorption via Engineering Anisotropic Plasmonic Spiky Au Nanocubes for the Highly Efficient Dual-Response Immune Detection of T-2 Toxin.
Anal Chem
December 2024
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Integrating specific immune recognition, a desirable extinction coefficient, and conspicuous photothermal conversion ability into a single-immune probe to enhance the analysis performance represents an appealing yet significantly challenging task. Herein, by delicately manipulating the geometry of plasmonic nanoparticles from spherical to spiky, precise engineering approach-based spiky Au nanocubes (S-AuNCs) are employed to address this challenge, which fully exploits the plasmon resonance absorption-induced photothermal effect. The finite difference time domain (FDTD) method was employed to computationally simulate the electromagnetic and thermal fields while assessing the feasibility of regulating plasmon resonance for enhanced photothermal absorption.
View Article and Find Full Text PDFShape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles.
Mol Pharm
January 2025
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Article Synopsis
- Gold nanoparticles (AuNPs) are key in various biomedical applications, but inconsistent toxicity results highlight the need for standardized testing methods.
- This study examines ten types of AuNPs with different shapes and sizes to evaluate their toxicity, revealing that shape and size significantly affect cytotoxicity levels.
- Findings indicate that smaller, anisotropic AuNPs tend to be more toxic and influence biodistribution and pharmacokinetics, underscoring the importance of tailoring nanoparticle design for drug delivery applications.
Gold nanostars and nanourchins for enhanced photothermal therapy, bioimaging, and theranostics.
J Mater Chem B
January 2025
School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, 64849 Monterrey, Nuevo León, Mexico.
Photothermal therapy (PTT), a recently emerging method for eradicating tumors, utilizes hyperthermia induced by photo-absorbing materials to generate heat within cancer cells. Gold nanoparticles (AuNPs) have gained reliability for and applications in PTT due to their strong light absorbance, stability, and biocompatibility. Yet, their potential is limited by their spherical shape, impacting their size capabilities, electromagnetic enhancement effects, and localized surface plasmon resonance (LSPR).
View Article and Find Full Text PDFShape anisotropy induced jamming of nanoparticles at liquid interfaces: a tensiometric study.
Nanoscale Adv
September 2024
Soft Matter and Nanomaterials Laboratory, Department of Physics, Indian Institute of Technology Bombay Mumbai 400 076 India +91-22-2576-7572.
The intersection of nanotechnology and interfacial science has opened up new avenues for understanding complex phenomena occurring at liquid interfaces. The assembly of nanoparticles at liquid/liquid interfaces provides valuable insights into their interactions with fluid interfaces, essential for various applications, including drug delivery. In this study, we focus on the shape and concentration effects of nanoscale particles on interfacial affinity.
View Article and Find Full Text PDFHybrid Nanogel-Wrapped Anisotropic Gold Nanoparticles Feature Enhanced Photothermal Stability.
Small
November 2024
POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia-San Sebastián, 20018, Spain.
Anisotropic gold nanoparticles (AuNPs) are renowned for their unique properties - including localized surface plasmon resonance (LSPR) and adjustable optical responses to light exposure - that enable the conversion of light into heat and make them a promising tool in cancer therapy. Nonetheless, their tendency to aggregate and consequently lose their photothermal conversion capacity during prolonged irradiation periods represents a central challenge in developing anisotropic AuNPs for clinical use. To overcome this issue, an innovative approach that facilitates the encapsulation of individual anisotropic AuNPs within thin nanogels, forming hybrid nanomaterials that mirror the inorganic core's morphology while introducing a negligible (2-8 nm) increase in overall diameter is proposed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!