AI Article Synopsis
- Kidney diseases are a major global health issue, leading to increased prevalence and economic burden, hence the need for new treatment approaches to improve patient outcomes.
- The review focuses on ferroptosis, a type of regulated cell death linked to iron and lipid metabolism, and explores its role in various kidney-related diseases.
- It discusses how targeting ferroptosis could be beneficial in treating conditions like acute kidney injury, chronic kidney disease, and diabetic nephropathy, and suggests the potential for using existing drugs and traditional medicine to develop new treatments.
Article Abstract
Kidney diseases are significant global public health concern, with increasing prevalence and substantial economic impact. Developing novel therapeutic approaches are essential for delaying disease progression and improving patient quality of life. Cell death signifying the termination of cellular life, could facilitate appropriate bodily development and internal homeostasis. Recently, regulated cell death (RCD) forms such as ferroptosis, characterized by iron-dependent lipid peroxidation, has garnered attention in diverse renal diseases and other pathological conditions. This review offers a comprehensive examination of ferroptosis, encompassing an analysis of the involvement of iron and lipid metabolism, the System Xc /glutathione/glutathione peroxidase 4 signaling, and additional associated pathways. Meanwhile, the review delves into the potential of targeting ferroptosis as a therapeutic approach in the management of acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy, and renal tumors. Furthermore, it emphasizes the significance of ferroptosis in the transition from AKI to CKD and further accentuates the potential for repurposing drug and utilizing traditional medicine in targeting ferroptosis-related pathways for clinical applications. The integrated review provides valuable insights into the role of ferroptosis in kidney diseases and highlights the potential for targeting ferroptosis as a therapeutic strategy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363859 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e35882 | DOI Listing |
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