Influence of diabetes on microbiome in prostate tissues of patients with prostate cancer.

Front Oncol

Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Republic of Korea.

Published: August 2024

AI Article Synopsis

  • * Analyzed 118 tissue samples (59 benign and 59 malignant) alongside 64 negative controls to minimize contamination in microbiome results.
  • * Findings indicate that diabetes significantly alters the microbiome in malignant prostate tissues, affecting cancer progression and highlighting the need for further investigation to enhance clinical therapy strategies.

Article Abstract

Background: Although microbiota in prostatic tissues of patients with prostate cancer have been studied, results of different studies have been inconsistent. Different ethnicity of study subjects, different study designs, and potential contaminations during sample collection and experiments might have influenced microbiome results of prostatic tissues. In this study, we analyzed microbiota and their potential functions in benign and malignant tissues of prostate cancer considering possible contaminants and host variables.

Materials And Methods: A total of 118 tissue samples (59 benign tissues and 59 malignant tissues) obtained by robot-assisted laparoscopic radical prostatectomy were analyzed and 64 negative controls (from sampling to sequencing processes) were included to reduce potential contaminants.

Results: Alteration of the microbiome in prostate tissues was detected only in patients with diabetes. Furthermore, the influence of diabetes on microbiome was significant in malignant tissues. The microbiome in malignant tissues of patients with diabetes was influenced by pathologic stages. The relative abundance of was reduced in the high pathologic group compared to that in the intermediate group. This reduction was related to microbial pathways increased in the high pathologic group.

Conclusion: Results of this study indicate that diabetes can influence the progression of prostate cancer with microbiome alteration in prostate tissues. Although further studies are necessary to confirm findings of this study, this study can help us understand tissue microbiome in prostate cancer and improve clinical therapy strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365045PMC
http://dx.doi.org/10.3389/fonc.2024.1445375DOI Listing

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