AI Article Synopsis

  • A study on perioperative antibiotic prophylaxis (PAP) in lung transplant recipients over a 20-year period revealed significant variation in practices among different centers.
  • The research enrolled 111 lung transplant recipients, finding that most received combination therapy, while the median duration for PAP was 10 days.
  • However, the study concluded that there was no significant difference in preventing early post-operative infections (EPOIs) between combination and single-agent therapies, and duration of PAP also did not impact EPOI rates.

Article Abstract

Perioperative antibiotic prophylaxis (PAP) in lung transplant recipients (LuTRs) has high heterogeneity between centers. Our aim was to investigate retrospectively the approach to PAP in our center over a 20-year period (2002-2023), and its impact on early post-operative infections (EPOIs) after lung transplantation (LuT). Primary endpoint was diagnosis of EPOI, defined as any bacterial infection including donor-derived events diagnosed within 30 days from LuT. Main exposure variables were type of PAP (combination vs. monotherapy) and PAP duration. We enrolled 111 LuTRs. PAP consisted of single-agent or combination regimens in 26 (25.2%) and 85 (74.8%) LuTR. Median PAP duration was 10 days (IQR 6-13) days. Piperacillin/tazobactam was the most common agent used either as monotherapy (n = 21, 80.7%) or as combination with levofloxacin (n = 79, 92.9%). EPOIs were diagnosed in 30 (27%) patients. At multivariable analysis no advantages were found for combination regimens compared to single-agent PAP in preventing EPOI (OR: 1.57, 95% CI: 0.488-5.068, p:0.448). The impact of PAP duration on EPOIs development was investigated including duration of PAP ≤6 days as main exposure variables, without finding a significantly impact (OR:2.165, 95% CI: 0.596-7.863, p: 0.240). Our results suggest no advantages for combination regimens PAP in preventing EPOI in LuTR.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361928PMC
http://dx.doi.org/10.3389/ti.2024.13245DOI Listing

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