Introduction: Health locus of control has the potential to influence health behavior among individuals with chronic diseases. However, little is known regarding the relationship between locus of control and physical activity in transplant recipients. The aim of the study was to investigate health locus of control and physical activity in liver transplant recipients.
Methods: Seventy-six liver transplant recipients were enrolled. The Multidimensional Health Locus of Control - Form C, including internal, chance, doctors, and powerful others subdimensions, was used to evaluate the health locus of control. Physical activity was assessed with the International Physical Activity Questionnaire - Short Form.
Results: The median internal health locus of control score was 28.54. Thirty-six participants had low, 35 participants had moderate, and five participants had high physical activity. Internal health locus of control was higher in patients having moderate activity compared to patients with low activity (p=0.04). "Doctors" subdimension of health locus of control was negatively correlated with walking (r=-0.38, p=0.02) and total activity scores among patients with low activity (r=-0.37, p=0.02).
Conclusion: Liver transplant recipients with moderate activity present higher internal health locus of control scores, suggesting a possible influence of physically active behavior on the beliefs of one's own control over disease management. As the activity level increases, the belief that health outcomes are largely the responsibility of health professionals decreases among liver transplant recipients with low activity. Promoting physical activity will help develop the control of one's own actions on health after liver transplantation.
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http://dx.doi.org/10.7759/cureus.65817 | DOI Listing |
HGG Adv
January 2025
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada; Department of Human Genetics, McGill University, Montréal, Québec, Canada; 5 Prime Sciences Inc, Montréal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Twin Research, King's College London, London, UK. Electronic address:
Identifying novel, high-yield drug targets is challenging and often results in a high failure rate. However, recent data indicates that leveraging human genetic evidence to identify and validate these targets significantly increases the likelihood of success in drug development. Two recent papers from Open Targets claimed that around half of FDA-approved drugs had targets with direct human genetic evidence.
View Article and Find Full Text PDFNutrients
January 2025
Epidemiology Unit, Istituto Dermopatico dell'Immacolata (IDI-IRCCS-FLMM), 00167 Rome, Italy.
Unlabelled: Single nucleotide polymorphisms (SNPs) found to be associated with Androgenetic Alopecia (AGA) to date, are characterized by an apparent reduced penetrance into the phenotype suggesting a role of other factors in the etiology of AGA.
Objective: We conducted a study to investigate the role of specific allelic variants in AGA controlling for nutritional and lifestyle factors.
Methods: Individual patterns of SNPs present in the baldness susceptibility locus at 20p11 (rs1160312 and rs6113491) or close to the androgen receptor (AR) gene in chromosome X (rs1041668) were investigated in 212 male subjects.
Pathogens
December 2024
Department of Parasitology, Faculty of Science, Charles University, 128 00 Prague, Czech Republic.
Bartonellae are zoonotic pathogens with a broad range of reservoir hosts and vectors. To examine sylvatic reservoirs, tissue samples of red deer (, = 114) and their associated deer keds (, = 50; , = 272) collected in the Czech Republic were tested for the presence of using PCR at four loci (, , , ITS); PCR sensitivity was increased significantly by using primers modified for the detection of wildlife-associated bartonellae. One-third of the deer and 70% of the deer keds were positive; within the tested animal tissues, usually the spleen was positive.
View Article and Find Full Text PDFInt J Legal Med
January 2025
Laboratory of Forensic and Population Genetics, Legal Medicine, Psychiatry and Pathology Department, Medicine School, Complutense University of Madrid, Madrid, 28040, Spain.
Under the initiative of the "Direcció General de Memòria democràtica-Departament de Justícia" (Generalitat of Catalonia, Spain), a multi-disciplinar project was funded to identify the remains of people disappeared in Catalonia during and after the Spanish Civil War (1936-1939). Samples were officially sent by Autonomous Government of Catalonia to the Laboratory of Forensic and Population Genetics at Complutense University, Madrid, Spain, to be genotyped. Our study presents a database of 343 victims genotyped for STRs comprised in GlobalFiler™ PCR Amplification Kit (Thermofisher Scientific) and a subset of 292 typed with Y-STRs from Yfiler™ Plus PCR Amplification Kit (Thermofisher Scientific).
View Article and Find Full Text PDFAm J Clin Nutr
January 2025
Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Background: Understanding gene-environment interactions associated with vitamin D status may refine nutrition and public health strategies for vitamin D deficiency. Recent methodological advances have enabled the identification of variance quantitative trait loci (vQTLs) where gene-environment interactions are enriched.
Objectives: To identify vQTLs for serum 25-hydroxy vitamin D (25OHD) concentrations and characterize potential gene-environment interactions of vQTLs.
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