AI Article Synopsis
- Charcot neuro-osteoarthropathy (CNO) primarily arises from diabetic neuropathy, leading to significant health complications and increasing healthcare demands worldwide.
- Effective treatment requires a multi-disciplinary team due to the complex and varied nature of the disease, which complicates the creation of comprehensive treatment guidelines.
- A literature review from 2003 to 2023 was conducted, resulting in an evidence-based algorithm to assist in surgical decision-making and enhance understanding of management strategies among the entire healthcare team.
Article Abstract
Charcot neuro-osteoarthropathy (CNO), mainly as a result of diabetic neuropathy, is a complex problem which carries significant morbidity, and is an increasing burden on healthcare as demographics change globally. A multi-disciplinary team (MDT) is necessary to treat the multiple facets of this disease. The multifactorial and non-homogenous nature of this condition and its management, has prevented the development of comprehensive guidelines based on level 1 evidence. Although there is a trend to surgically treat these patients in tertiary centres, the increasing prevalence of CNO necessitates the capability of all units to manage this condition to an extent locally. This article conducted a thorough literature search of Pubmed and Embase from 2003 to 2023 including the following search terms; "Charcot" "neuroarthropathy" "diabetic foot" "management" "surgery" "treatment" "reconstruction". The results of this review have been summarised and synthesised into an evidence-based algorithm to aid in the surgical decision-making process, and improve the understanding of surgical management by the whole MDT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362032 | PMC |
| http://dx.doi.org/10.3389/fcdhc.2024.1344359 | DOI Listing |
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Aim: Diabetic Charcot neuro-osteoarthropathy carries a significant worldwide disease burden including diabetic foot infection, ulceration and amputation. The current accepted standard of treatment during the active phase of Charcot neuro-osteoarthropathy is offloading with total contact casting; however, controversy remains regarding weight-bearing status during this period.
Methods: A systematic review was performed following PRISMA guidelines of Pubmed, EMBASE, MEDLINE and the Cochrane central register of controlled trials for clinical studies from inception until June 2024 investigating weight-bearing and non-weight-bearing total contact casting for active Charcot neuro-osteoarthropathy.
Charcot neuro-osteoarthropathy: a review of key concepts and an evidence-based surgical management algorithm.
Front Clin Diabetes Healthc
August 2024
East and North Hertfordshire NHS Trust, Stevenage, United Kingdom.
Article Synopsis
- Charcot neuro-osteoarthropathy (CNO) primarily arises from diabetic neuropathy, leading to significant health complications and increasing healthcare demands worldwide.
- Effective treatment requires a multi-disciplinary team due to the complex and varied nature of the disease, which complicates the creation of comprehensive treatment guidelines.
- A literature review from 2003 to 2023 was conducted, resulting in an evidence-based algorithm to assist in surgical decision-making and enhance understanding of management strategies among the entire healthcare team.
Anti-RANKL Antibody For Active Charcot Foot Neuro-Osteoarthropathy in Patients with Diabetes and Chronic Kidney Disease.
Foot Ankle Int
October 2024
Department of Endocrinology, Alchemist Hospitals, Panchkula, India.
Background: Charcot neuroosteoarthropathy (CNO) is characterized with increased osteoclastic activity that can be curbed with antiresorptive agents. Chronic kidney disease (CKD) precludes bisphosphonates but anti-receptor activator of nuclear factor-B ligand (anti-RANKL) antibody, denosumab, can be contemplated in CKD. We investigated denosumab for active CNO of foot in CKD for CNO remission.
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