Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.

Drug Des Devel Ther

Zhanjiang Key Laboratory of Orthopaedic Technology and Trauma Treatment, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, 524037, People's Republic of China.

Published: September 2024

AI Article Synopsis

  • * Although the use of polydopamine in preventing and treating orthopedic diseases is still in its early phases, there have been some promising initial results.
  • * This article reviews the properties and types of polydopamine biomaterials, discusses their potential in orthopedic applications, and addresses the challenges and future opportunities for developing effective polydopamine solutions for clinical use.

Article Abstract

Polydopamine is a versatile and modifiable polymer, known for its excellent biocompatibility and adhesiveness. It can also be engineered into a variety of nanoparticles and biomaterials for drug delivery, functional modification, making it an excellent choice to enhance the prevention and treatment of orthopedic diseases. Currently, the application of polydopamine biomaterials in orthopedic disease prevention and treatment is in its early stages, despite some initial achievements. This article aims to review these applications to encourage further development of polydopamine for orthopedic therapeutic needs. We detail the properties of polydopamine and its biomaterial types, highlighting its superior performance in functional modification on nanoparticles and materials. Additionally, we also explore the challenges and future prospects in developing optimal polydopamine biomaterials for clinical use in orthopedic disease prevention and treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363944PMC
http://dx.doi.org/10.2147/DDDT.S473007DOI Listing

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