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Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases.
Biomater Sci
January 2025
Department of Molecular Bioscience, The University of Texas at Austin, Austin, Texas 78712, USA.
Extracellular vesicles (EVs) are secreted by almost all cell types and contain DNA, RNA, proteins, lipids and other metabolites. EVs were initially believed to be cellular waste but now recognized for their role in cell-to-cell communication. Later, EVs from immune cells were discovered to function similarly to their parent cells, paving the way for their use as gene and drug carriers.
View Article and Find Full Text PDFThe biodiversity of ice-free Antarctica database.
Ecology
January 2025
Securing Antarctica's Environmental Future, School of Biological Sciences, Monash University, Melbourne, Victoria, Australia.
Antarctica is one of Earth's most untouched, inhospitable, and poorly known regions. Although knowledge of its biodiversity has increased over recent decades, a diverse, wide-ranging, and spatially explicit compilation of the biodiversity that inhabits Antarctica's permanently ice-free areas is unavailable. This absence hinders both Antarctic biodiversity research and the integration of Antarctica in global biodiversity-related studies.
View Article and Find Full Text PDFGeorgios Photeinos and his (1835) published in Ottoman Smyrna.
Pharmazie
December 2024
Department of the History of Pharmacy and Ethics, Erciyes University Faculty of Pharmacy, Kayseri, Turkey.
The , authored by Ottoman pharmacist Georgios Photeinos and published in 1835 in Smyrna (modern-day Izmir, T??rkiye), is a historically significant yet largely overlooked work in 19th-century pharmaceutical literature. At a time when modern pharmaceutical resources in Greek were scarce, Photeinos sought to address this gap by creating a comprehensive pharmacopoeia that extensively drew from the Austrian Pharmacopoeia, as well as French and Latin sources. Although he initiated the project around 1804, political upheavals delayed its completion by more than three decades.
View Article and Find Full Text PDFArticle Synopsis
- The field of formal nursing ethics has evolved significantly over 30 years, with a marked increase in publications and diversity in geographical contributions, moving beyond North American roots.
- There has been a shift in research methodologies from a philosophical approach to a greater emphasis on empirical research, particularly quantitative studies.
- Key topics of focus have emerged, including moral distress, ethical climate, and ethics education, prompting discussions on future directions for nursing ethics scholarship.
Real World Evidence From 2 Decades of First-Line TKI Therapy in Chronic Myeloid Leukemia (CML): Insights From ACHO's RENEHOC Registry.
Clin Lymphoma Myeloma Leuk
December 2024
Clinica IMAT Oncomedica Auna S.A.S, Montería, Colombia.
Background: Chronic myeloid leukemia (CML) treatment has significantly evolved with the introduction of tyrosine kinase inhibitors. However, access to these treatments and outcomes vary globally. This study examines 2 decades of CML management in Colombia using the RENEHOC registry, focusing on TKI efficacy, safety, and healthcare system challenges.
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