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Safety, feasibility, and incremental value of ultralow and zero contrast PCI in an all-comers registry. | LitMetric

AI Article Synopsis

  • Patients with chronic kidney disease and coronary artery disease (CAD) often face risks during standard revascularization due to potential acute renal failure from contrast exposure, which has limited the use of ultra-low and zero contrast procedures.
  • A study conducted over 18 months with 200 patients compared outcomes between those who underwent ultra-low/zero contrast percutaneous coronary intervention (PCI) and those receiving standard PCI, revealing significantly lower rates of contrast-induced acute kidney injury (AKI) in the ULC/ZC group.
  • The findings suggest that ultra-low/zero contrast PCI is a safe and effective option for patients with complex lesions, showing lower rates of renal function decrement and no increase in mortality or major complications compared to traditional methods.

Article Abstract

Background: Patients with chronic kidney disease and CAD have been denied revascularization because of fear of precipitating acute renal failure from contrast exposure. Skepticism on whether Ultra-Low contrast percutaneous coronary intervention (PCI) or Zero contrast PCI (ULC/ZC PCI) can be safely performed has limited its adoption.

Methods: This observational registry enrolled 200 consecutive patients referred for elective PCI at a single center from June 2021 to December 2022. The study investigated whether the clinical outcomes of PCI performed with UL/ZC-PCI (n-48) were comparable to outcomes following standard PCI (n-152).

Results: Both groups were well matched in baseline and procedural characteristics. The groups had a highly statistical difference in the use of CV. Mean CV was 19.17 ± 7.29 cc in the ULC/ZC-group and 147.14 ± 73.55 cc in the control arm. The principal findings of the study were that the incidence of ontrast-induced acute kidney injury (AKI) was eightfold lower in patients receiving UL/ZC compared to the control group that received standard PCI. The incidence of all-cause mortality, myocardial infarction and major bleeding were similar in both groups. At 6 months, the decrement in renal function was lower in the group that received lower volumes of contrast.

Conclusions: This single center observational registry demonstrated that UL-C/ZC-PCI is safe and effective in a broad spectrum of complex lesions. The skillsets needed to perform this are teachable, widely applicable and do not require a large upgrade of capital equipment. AKI rates and decrement in renal function at 6 months were both significantly lower in the UL-ZC group.

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Source
http://dx.doi.org/10.1002/ccd.31214DOI Listing

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