AI Article Synopsis
- * A 3D numerical model was created to analyze the transport behaviors of small molecule bilirubin and macromolecule bovine serum albumin (BSA) influenced by various flow rates and fiber lengths.
- * Results indicated that bilirubin clearance relies on both convective and diffusive transport, while BSA clearance is primarily due to convective transport; increasing flow rates generally improved clearance rates, with distinct behaviors observed for bilirubin and BSA under varying conditions.
Article Abstract
Understanding the mass transfer behaviors in hollow fiber membrane module of artificial liver is important for improving toxin removal efficiency. A three-dimensional numerical model was established to study the mass transfer of small molecule bilirubin and macromolecule bovine serum albumin (BSA) in the hollow fiber membrane module. Effects of tube-side flow rate, shell-side flow rate, and hollow fiber length on the mass transfer of bilirubin and BSA were discussed. The simulation results showed that the clearance of bilirubin was significantly affected by both convective and diffusive solute transport, while the clearance of macromolecule BSA was dominated by convective solute transport. The clearance rates of bilirubin and BSA increasd with the increase of tube-side flow rate and hollow fiber length. With the increase of shell-side flow rate, the clearance rate of bilirubin first rose rapidly, then slowly rose to an asymptotic value, while the clearance rate of BSA gradually decreased. The results can provide help for designing structures of hollow fiber membrane module and operation parameters of clinical treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366472 | PMC |
| http://dx.doi.org/10.7507/1001-5515.202311011 | DOI Listing |
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