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In Regard to Ethan B. Ludmir et al.
Pract Radiat Oncol
September 2024
Section of Radiation Oncology, Aga Khan University Hospital, Karachi, Pakistan.
A structural comparison of salt forms of dopamine with the structures of other phenylethylamines.
Acta Crystallogr C Struct Chem
October 2023
Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, United Kingdom.
Article Synopsis
- The study reports the structures of four different salt forms of dopamine, each with distinct chemical compositions.
- In these structures, the dopamine cation shows an extended conformation, and while some intermolecular interactions are similar to those in tyramine, the hydrogen bonding in dopamine is more variable.
- Packing analysis reveals that the dopamine salts can be grouped based on cation positioning, with some groups including both dopamine and tyramine, demonstrating the complexity of packing behavior despite differences in intermolecular interactions.
Targeting AKT2 in MDA-MB-231 Cells by Pyrazole Hybrids: Structural, Biological and Molecular Docking Studies.
Chem Biodivers
November 2023
Department of Chemistry, MES, Abasaheb Garware College, Pune, Maharashtra, India-, 411004.
Pyrazolic hybrids appended with naphthalene, p-chlorobenzene, o-phenol and toluene have been synthesized using Claisen Schmidt condensation reaction of 1-benzyl-3,5-dimethyl-1H-pyrazole-4-carbaldehyde. All compounds were characterized by various spectroscopic techniques. Compound (E)-3-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-1-(4-chlorophenyl)prop-2-en-1-one crystallizes in monoclinic crystal system with C2/c space group.
View Article and Find Full Text PDFOrganisational capabilities, outcomes, and benefits of trigger finger release surgery in primary care: a service evaluation study.
BJGP Open
December 2023
NHS Willows Health, Leicester, UK
Background: Trigger finger is a common hand condition in which a finger is unable to fully extend owing to a thickening of the tendon and its sheath, causing the finger to lock in a bent position.
Aim: To assess the viability of carrying out trigger finger surgeries in NHS primary care in terms of clinician and patient acceptance, experience, and outcomes; and operational requirements of this service for wider application.
Design & Setting: A pilot study for a new service in primary care in Leicestershire, UK.
Genome-wide Association Identifies Novel Etiological Insights Associated with Parkinson's Disease in African and African Admixed Populations.
medRxiv
May 2023
College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.
Article Synopsis
- The study focuses on understanding genetic factors contributing to Parkinson's disease (PD) within African and African admixed populations to advance precision medicine.
- A genome-wide assessment involving nearly 200,000 individuals identified a significant risk factor linked to the gene at locus rs3115534-G, with a strong correlation to PD onset and a mechanism related to gene expression rather than coding mutations.
- The findings suggest this genetic variant is uniquely prevalent among African ancestries, highlighting the importance of diverse populations in researching complex diseases like PD.
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