Assessment of health-related quality of life in patients with nontuberculous mycobacterial pulmonary disease: A comprehensive review.

Respir Investig

Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan; Department of Clinical Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. Electronic address:

Published: November 2024

AI Article Synopsis

  • The global rise in nontuberculous mycobacterial pulmonary disease (NTM-PD) presents challenges in achieving bacterial clearance and managing high rates of recurrence.
  • The focus on patient-reported outcomes (PROs) emphasizes their significance in understanding how NTM-PD impacts health-related quality of life (HRQoL), which is notably affected by the disease's prognosis.
  • Evaluating HRQoL through relevant PRO tools allows for better patient-centered care, particularly for those experiencing refractory NTM-PD and declining quality of life over time.

Article Abstract

The global incidence of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing. The primary aim of pharmacotherapeutic treatment for NTM-PD is to achieve negative bacterial conversion, but this goal is challenging, especially in cases with poor prognosis factors. Moreover, recurrence frequently occurs following successful treatment. Consequently, patient-reported outcomes (PROs) have attracted an increasing amount of attention due to their potential to elucidate the pathophysiology of NTM-PD. The current review article aimed to describe the current understanding of PROs related to health-related quality of life (HRQoL). HRQoL is influenced by a variety of factors; notably, those factors associated with the prognosis of NTM-PD significantly impair HRQoL. In patients with refractory NTM-PD, HRQoL tends to worsen over time. Assessing HRQoL through PROs involves short-term or long-term evaluation tools, which are selected based on their relevance to the patient's condition and the clinician's goals. Understanding the nuances of PROs can be helpful for delivering empathetic care tailored to patients in even the most complex treatment scenarios.

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Source
http://dx.doi.org/10.1016/j.resinv.2024.08.009DOI Listing

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