Post-traumatic arthritis (PTA) of the knee is a complex problem, requiring foresight and careful preoperative planning. Each case of PTA is unique, requiring understanding of the altered anatomy, management of any retained hardware, and also the ability to provide the appropriate stability for each affected knee. Successful treatment of PTA with total knee arthroplasty (TKA) requires the creation of stable and well-balanced joint. TKA for PTA provides comparable improvements in pain and function when compared with primary osteoarthritis, however, these patients are at increased risk of post-operative complications, including instability and infection.
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http://dx.doi.org/10.1016/j.ocl.2024.04.002 | DOI Listing |
Hand Surg Rehabil
January 2025
AOU di Modena - SC Chirurgia della Mano, Italy.
Most patients with post-traumatic and/or degenerative wrist arthritis present with pain and limitation of activities of daily living. Wrist denervation using a two-incision technique is an alternative to proximal row carpectomy and partial or total wrist arthrodesis. The purpose of this study was to evaluate whether two-incision denervation is a valid procedure for reducing pain in wrist arthritis of different etiologies.
View Article and Find Full Text PDFPLoS One
January 2025
Division of Arthroscopic and special Joint Surgery / Sports Injuries, Department of Orthopedics, Trauma and Plastic Surgery, University of Leipzig, Leipzig, Germany.
Background: The number of reverse shoulder arthroplasty (RSA) procedures performed worldwide has increased over the last 10 years, with a corresponding increase in revision shoulder arthroplasty (SRSA). SRSA is often used for post-traumatic revision surgery in cases of infections and failure of anatomical prostheses. Data on outcomes with specific detail for each indication for the prosthetic solution as a secondary treatment are scarce, and inhomogeneous.
View Article and Find Full Text PDFPLoS One
January 2025
Lawrence Livermore National Laboratory, Physical and Life Science Directorate, Livermore, CA, United States of America.
Post-traumatic osteoarthritis (PTOA) is a painful joint disease characterized by the degradation of bone, cartilage, and other connective tissues in the joint. PTOA is initiated by trauma to joint-stabilizing tissues, such as the anterior cruciate ligament, medial meniscus, or by intra-articular fractures. In humans, ~50% of joint injuries progress to PTOA, while the rest spontaneously resolve.
View Article and Find Full Text PDFJ Hand Surg Eur Vol
January 2025
Hand & Wrist Unit, Genolier Campus, Vaud, Switzerland.
JCI Insight
December 2024
Institute of Musculoskeletal Medicine, University Hospital Münster, Münster, Germany.
Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane, crucial for refilling depleted internal calcium stores during activation of calcium-dependent signaling pathways. Here, we demonstrate that TRPC1 activity is protective within cartilage homeostasis in the prevention of cellular senescence associated cartilage breakdown during mechanical and inflammatory challenge. We reveal that TRPC1 loss is associated with early stages of osteoarthritis (OA) and plays a non-redundant role in calcium signaling in chondrocytes.
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