AI Article Synopsis
- The study aimed to analyze how often home, non-intravenous benzodiazepines (non-IV-rBZDs) are prescribed for kids experiencing febrile seizures and identify factors influencing these prescriptions.
- Using data from a significant database spanning 2006 to 2022, the research examined a sample of 82,835 children aged 6 months to 5 years who had febrile seizures.
- Results showed that only about 12% filled a prescription for non-IV-rBZD, with key factors like having complex febrile seizures or being hospitalized for seizures being strongly linked to whether a prescription was given.
Article Abstract
Objective: To describe the prescription patterns of home, non-intravenous rescue benzodiazepines (non-IV-rBZDs) for febrile seizures and the factors associated with their prescription.
Methods: Retrospective descriptive study using the MarketScan Commercial Database, a large database of employer-sponsored privately insured patients in the United States. We used data from January 1st 2006 to December 31st 2022. We studied patients with febrile seizures as the main code for the healthcare encounter (identified with International Classification of Diseases codes) with age from 6 months to 5 years of age and with at least 1 month of follow-up.
Results: There were a total of 82,835 patients [median (p-p) age 1.0 (1.0-2.0) years, 56.7 % males] with at least one febrile seizure, of whom 9,737 (11.8 %) filled at least one non-IV-rBZD prescription. Among the 9,737 patients who filled at least one prescription, the median (p-p) time from first febrile seizure to non-IV-rBZD prescription was 27 (2-186) days. Among the factors known at the time of the first febrile seizure, complex febrile seizure (OR: 3.51, 95 % CI: 3.24-3.79), and an initial inpatient hospitalization for febrile seizure (OR: 3.53, 95 % CI: 3.29-3.79) were the factors most strongly associated with filling a non-IV-rBZD prescription. In contrast, sex, rural patient's residence, and salary employment (versus other employment class) were not independently associated with filling a non-IV-rBZD prescription. Among the factors known at the end of follow-up, complex febrile seizures, type of initial encounter, and an eventual diagnosis of epilepsy were major independent factors associated with filling a non-IV-rBZD prescription.
Conclusion: Only approximately 12 % of children with a febrile seizure filled a prescription for a home non-IV-rBZD. The major factors independently associated with prescription were complex febrile seizure, hospital admission, recurrent febrile seizures, and an eventual diagnosis of epilepsy.
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| http://dx.doi.org/10.1016/j.seizure.2024.08.018 | DOI Listing |
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